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Details

Stereochemistry RACEMIC
Molecular Formula C19H23ClN2.2ClH
Molecular Weight 387.774
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HOMOCHLORCYCLIZINE DIHYDROCHLORIDE

SMILES

Cl.Cl.CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=JLVFQWFTNVMTEG-UHFFFAOYSA-N
InChI=1S/C19H23ClN2.2ClH/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17;;/h2-4,6-11,19H,5,12-15H2,1H3;2*1H

HIDE SMILES / InChI

Description

Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
Homoclomin
Primary
Homoclomin
Primary
Homoclomin

PubMed

Sample Use Guides

In Vivo Use Guide
The usual adult dosage for oral use is 1 to 2 tablets (10 - 20 mg of homochlorcyclizine hydrochloride) three times daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown