Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H23ClN2.2ClH |
Molecular Weight | 387.774 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3
InChI
InChIKey=JLVFQWFTNVMTEG-UHFFFAOYSA-N
InChI=1S/C19H23ClN2.2ClH/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17;;/h2-4,6-11,19H,5,12-15H2,1H3;2*1H
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14409112Curator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14409112
Curator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry. | 2006 |
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A similarity search using molecular topological graphs. | 2009 |
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Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
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Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
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m6041
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SUB02534MIG
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CHEMBL1515447
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1982-36-1
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24342-55-0
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ACTIVE MOIETY
SUBSTANCE RECORD