Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H9NO4.ClH |
| Molecular Weight | 183.59 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.N[C@@H](CCC(O)=O)C(O)=O
InChI
InChIKey=RPAJSBKBKSSMLJ-DFWYDOINSA-N
InChI=1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
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Target ID: CHEMBL2109241 |
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Target ID: CHEMBL2096670 |
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Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots. | 2001 |
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| Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. | 2001 |
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| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001 Apr 6 |
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| Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions. | 2001 Dec |
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| Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes. | 2001 Mar 2 |
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| Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase. | 2001 Sep |
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| Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. | 2001 Sep |
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| Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons. | 2002 Jul-Aug |
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| Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. | 2002 Nov 1 |
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| FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. | 2003 |
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| Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. | 2003 Jul |
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| Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
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| Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. | 2004 Apr |
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| Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
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| RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts. | 2004 Dec 3 |
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| Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures. | 2004 Jul |
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| Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. | 2005 Dec |
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| Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb. | 2005 Sep |
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| Nonsense-mediated mRNA decay mutation in Aspergillus nidulans. | 2006 Nov |
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| Neuro-bioenergetic concepts in cancer prevention and treatment. | 2007 |
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| Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. | 2007 Apr 6 |
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| Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana. | 2007 Mar |
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| Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia. | 2007 Oct |
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| Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. | 2008 |
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| Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. | 2008 Dec |
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| Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
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| Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects. | 2008 Jul |
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| Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
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| Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase. | 2009 Dec 14 |
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| Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. | 2009 Dec 23 |
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| Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. | 2009 Jan 5 |
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| Receptors and transduction of umami taste stimuli. | 2009 Jul |
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| Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. | 2009 Jun |
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| A role for Melanin-Concentrating Hormone in learning and memory. | 2009 Nov |
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| Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. | 2009 Oct |
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| Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population. | 2009 Oct |
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| Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure. | 2009 Oct |
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| Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations. | 2009 Sep 8 |
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| The functional organisation of glia in the adult brain of Drosophila and other insects. | 2010 Apr |
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| Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 Feb 10 |
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| 1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model. | 2010 Jul |
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| Cannabinoids excite circadian clock neurons. | 2010 Jul 28 |
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| Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. | 2010 Jun 26 |
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| Cholinergic modulation of fast inhibitory and excitatory transmission to pedunculopontine thalamic projecting neurons. | 2010 May |
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| Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions. | 2010 Nov 26 |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
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WHO-ATC |
A09AB01
Created by
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WHO-VATC |
QA09AB01
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CFR |
21 CFR 310.540
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CFR |
21 CFR 172.320
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NCI_THESAURUS |
C78276
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2723891
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DTXSID6047155
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m5775
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M0C2SP444T
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1294987
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9239
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100000078194
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CHEMBL1255943
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91269
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138-15-8
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M0C2SP444T
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138-15-8
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C28515
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SUB13989MIG
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DBSALT002484
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205-315-9
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ACTIVE MOIETY
SUBSTANCE RECORD
