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Details

Stereochemistry ACHIRAL
Molecular Formula C26H29NO3.ClH
Molecular Weight 439.974
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMOTRIPHENE HYDROCHLORIDE

SMILES

Cl.COC1=CC=C(C=C1)C(CN(C)C)=C(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3

InChI

InChIKey=KZILRTFVGWVPLE-UHFFFAOYSA-N
InChI=1S/C26H29NO3.ClH/c1-27(2)18-25(19-6-12-22(28-3)13-7-19)26(20-8-14-23(29-4)15-9-20)21-10-16-24(30-5)17-11-21;/h6-17H,18H2,1-5H3;1H

HIDE SMILES / InChI

Description

Amotriphene (Myordil, WIN 5494) is a coronary dilator and cardiac antiarrhythmic properties. It has potential value in the treatment of angina-like conditions and the milder cardiac arrhythmias. Amotriphene binds to α‐adrenergic receptors.

Originator

Sterling Drug
16

Approval Year

Unknown
139,594

PubMed

Patents

US3010965
2
WO2006130174A2
2

Sample Use Guides

In Vivo Use Guide
Dogs: Amotriphene was administered intravenously in increments of 2.0 mg/Kg at 5-minute intervals until the arrhythmia was converted to a normal sinus rhythm or until heart block occurred.
Route of Administration: Intravenous
PARENT (SALT/SOLVATE)
Structure of AMOTRIPHENE
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