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Details

Stereochemistry ACHIRAL
Molecular Formula C26H29NO3.ClH
Molecular Weight 439.974
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMOTRIPHENE HYDROCHLORIDE

SMILES

Cl.COC1=CC=C(C=C1)C(CN(C)C)=C(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3

InChI

InChIKey=KZILRTFVGWVPLE-UHFFFAOYSA-N
InChI=1S/C26H29NO3.ClH/c1-27(2)18-25(19-6-12-22(28-3)13-7-19)26(20-8-14-23(29-4)15-9-20)21-10-16-24(30-5)17-11-21;/h6-17H,18H2,1-5H3;1H

HIDE SMILES / InChI
Molecular Formula C26H29NO3
Molecular Weight 403.5134
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Amotriphene (Myordil, WIN 5494) is a coronary dilator and cardiac antiarrhythmic properties. It has potential value in the treatment of angina-like conditions and the milder cardiac arrhythmias. Amotriphene binds to α‐adrenergic receptors.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Clinical observations of amotriphene hydrochloride.
1961 Dec 1
A PRELIMINARY CLINICAL STUDY OF AMOTRIPHENE, AN ANTIARRHYTHMIC DRUG.
1964 Oct
Heterogeneity of biochemical actions among vasodilators.
1982 Jan
Patents

Patents

US3010965
2
WO2006130174A2
2

Sample Use Guides

In Vivo Use Guide
Dogs: Amotriphene was administered intravenously in increments of 2.0 mg/Kg at 5-minute intervals until the arrhythmia was converted to a normal sinus rhythm or until heart block occurred.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:25:14 GMT 2023
Edited
by admin
on Fri Dec 15 16:25:14 GMT 2023
Record UNII
M02V9BH3D0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMOTRIPHENE HYDROCHLORIDE
Common Name English
3-DIMETHYLAMINO-1,1,2-TRIS(4-METHOXYPHENYL)-1-PROPENE HYDROCHLORIDE
Systematic Name English
AMINOOXYTRIPHENE HYDROCHLORIDE
Common Name English
WIN 5494
Code English
AMINOOXYTRIPHENE HCL
Common Name English
WIN-5494 HYDROCHLORIDE
Code English
Code System Code Type Description
EPA CompTox
DTXSID40205350
Created by admin on Fri Dec 15 16:25:14 GMT 2023 , Edited by admin on Fri Dec 15 16:25:14 GMT 2023
PRIMARY
FDA UNII
M02V9BH3D0
Created by admin on Fri Dec 15 16:25:14 GMT 2023 , Edited by admin on Fri Dec 15 16:25:14 GMT 2023
PRIMARY
CAS
568-69-4
Created by admin on Fri Dec 15 16:25:14 GMT 2023 , Edited by admin on Fri Dec 15 16:25:14 GMT 2023
PRIMARY
PUBCHEM
11282
Created by admin on Fri Dec 15 16:25:14 GMT 2023 , Edited by admin on Fri Dec 15 16:25:14 GMT 2023
PRIMARY
Related Record Type Details
Structure of AMOTRIPHENE
PARENT -> SALT/SOLVATE
NIH
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