AMOTRIPHENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H29NO3
Molecular Weight	403.5134
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C(CN(C)C)=C(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3

InChI

InChIKey=FRQGJOFRWIILCX-UHFFFAOYSA-N

InChI=1S/C26H29NO3/c1-27(2)18-25(19-6-12-22(28-3)13-7-19)26(20-8-14-23(29-4)15-9-20)21-10-16-24(30-5)17-11-21/h6-17H,18H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C26H29NO3
Molecular Weight	403.5134
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.sciencedirect.com/science/article/pii/0002870361905531 | https://www.ncbi.nlm.nih.gov/pubmed/14215063 | https://www.ncbi.nlm.nih.gov/pubmed/13821528 | https://www.ncbi.nlm.nih.gov/pubmed/6276530

Amotriphene (Myordil, WIN 5494) is a coronary dilator and cardiac antiarrhythmic properties. It has potential value in the treatment of angina-like conditions and the milder cardiac arrhythmias. Amotriphene binds to α‐adrenergic receptors.

Originator

Approval Year

PubMed

Title	Date	PubMed
Clinical observations of amotriphene hydrochloride.	1961 Dec 1	13904871
A PRELIMINARY CLINICAL STUDY OF AMOTRIPHENE, AN ANTIARRHYTHMIC DRUG.	1964 Oct	14215063
Heterogeneity of biochemical actions among vasodilators.	1982 Jan	6276530

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: Amotriphene was administered intravenously in increments of 2.0 mg/Kg at 5-minute intervals until the arrhythmia was converted to a normal sinus rhythm or until heart block occurred.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:48 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:48 GMT 2023`
Record UNII	5VO63T4936
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMOTRIPHENE

Common Name

English

WIN-5494

Code

English

AMINOXYTRIPHENE

Official Name

English

MYORDIL

Brand Name

English

3-DIMETHYLAMINO-1,1,2-TRIS(4-METHOXYPHENYL)-1-PROPENE

Systematic Name

English

aminoxytriphene [INN]

Common Name

English

AMOTRIPHENE [MI]

Common Name

English

2,3,3-TRIS(P-METHOXYPHENYL)-N,N-DIMETHYLALLYLAMINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793