Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H11N3 |
| Molecular Weight | 125.1716 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=NC(CCN)=C1
InChI
InChIKey=FHQDWPCFSJMNCT-UHFFFAOYSA-N
InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3
1-Methylhistamine also known as tele-methylhistamine can be found primarily in most biofluids, including cerebrospinal fluid (CSF), urine, feces, and blood, as well as in human bone marrow, brain, and mast cell tissues; it is involved in histidine metabolism. This endogenous compound can be a marker of the inflammatory bowel disease because during the development of the disease it concentration is enhanced. Besides, experiments on dogs have revealed, that 1-methylhistamine can be used as a marker of intestinal inflammation in chronic gastrointestinal disease.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Platelet monoamine oxidase activity in megaloblastic anaemia. | 1980 Oct |
|
| Circulating histamine and eosinophil cationic protein levels in nocturnal asthma. | 1992 Aug |
|
| Determination of 1-methylhistamine and 1-methylimidazoleacetic acid in human urine as a tool for the diagnosis of mastocytosis. | 1999 Jan 8 |
|
| Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. | 2000 Jun |
|
| Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. | 2001 Mar |
|
| Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma. | 2001 Nov |
|
| Dynamics of histamine H(3) receptor antagonists on brain histamine metabolism: do all histamine H(3) receptor antagonists act at a single site? | 2001 Nov 16 |
|
| Urinary histamine metabolite elevations during experimental influenza infection. | 2001 Oct |
|
| Can urinary N-tele methylimidazoleacetic acid (t-MeImAA) serve as a marker of histaminergic activity in hepatic encephalopathy (HE)? | 2002 Apr |
|
| Human kidney diamine oxidase: heterologous expression, purification, and characterization. | 2002 Jun |
|
| Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy. | 2002 Jun |
|
| Urinary N-methylhistamine as an indicator of bone marrow involvement in mastocytosis. | 2002 Sep |
|
| Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population. | 2003 Apr |
|
| Suppressed weight gain following chronic I-histidine loading--involvement of neuronal histaminergic system? | 2003 Apr |
|
| Brain histamine turnover and seizure behaviour in two mouse strains: preliminary findings. | 2003 Apr |
|
| Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. | 2003 Nov |
|
| Decreased histamine-stimulated phosphoinositide hydrolysis in the cerebral cortex of a rat line selectively bred for high alcohol preference. | 2004 Jul |
|
| The role of the central histaminergic system on schizophrenia. | 2004 Jul-Aug |
|
| Comparison of serum tryptase and urine N-methylhistamine in patients with suspected mastocytosis. | 2005 Sep |
|
| Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. | 2006 Apr |
|
| Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial. | 2006 Jul 15 |
|
| Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism. | 2006 May |
|
| Rapid determination of histamine and its metabolites in mice hair by ultra-performance liquid chromatography with time-of-flight mass spectrometry. | 2006 Nov 3 |
|
| N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. | 2006 Sep |
|
| Protein properties of mackerel viscera extracted by supercritical carbon dioxide. | 2008 Jul |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008 Jun 6 |
|
| Bioelimination of histamine in epithelia of the porcine proximal colon of pigs. | 2009 May |
|
| Inhibition of basophil activation by histamine: a sensitive and reproducible model for the study of the biological activity of high dilutions. | 2009 Oct |
|
| Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B). | 2011 Oct 27 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
KCB81T4EOF
Created by
admin on Fri Dec 15 19:39:55 GMT 2023 , Edited by admin on Fri Dec 15 19:39:55 GMT 2023
|
PRIMARY | |||
|
29009
Created by
admin on Fri Dec 15 19:39:55 GMT 2023 , Edited by admin on Fri Dec 15 19:39:55 GMT 2023
|
PRIMARY | |||
|
66736
Created by
admin on Fri Dec 15 19:39:55 GMT 2023 , Edited by admin on Fri Dec 15 19:39:55 GMT 2023
|
PRIMARY | |||
|
501-75-7
Created by
admin on Fri Dec 15 19:39:55 GMT 2023 , Edited by admin on Fri Dec 15 19:39:55 GMT 2023
|
PRIMARY | |||
|
DTXSID30198207
Created by
admin on Fri Dec 15 19:39:55 GMT 2023 , Edited by admin on Fri Dec 15 19:39:55 GMT 2023
|
PRIMARY | |||
|
3614
Created by
admin on Fri Dec 15 19:39:55 GMT 2023 , Edited by admin on Fri Dec 15 19:39:55 GMT 2023
|
PRIMARY |
PARENT (METABOLITE INACTIVE)
SUBSTANCE RECORD
