U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N2O2.ClH
Molecular Weight 230.691
Optical Activity ( + )
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Solriamfetol Hydrochloride

SMILES

Cl.N[C@@H](COC(N)=O)CC1=CC=CC=C1

InChI

InChIKey=KAOVAAHCFNYXNJ-SBSPUUFOSA-N
InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1

HIDE SMILES / InChI

Description

ADX-N05, originally discovered by SK Holdings, is a selective dopamine and norepinephrine reuptake inhibitor (DNRI). ADX-N05 (Solriamfetol, sold under the brand name Sunosi) is approved in the US and is under regulatory review in the EU to improve wakefulness in adult patients with hypersomnia associated with narcolepsy or obstructive sleep apnoea.The US FDA has approved solriamfetol (Sunosi, Jazz Pharmaceuticals) for the treatment of excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea.The dual-acting dopamine and norepinephrine reuptake inhibitor is approved for narcolepsy in once-daily 75 mg and 150 mg doses, and in obstructive sleep apnea in once-daily 37.5 mg, 75 mg, and 150 mg doses.

Originator

Approval Year

2019
334
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 2.9 µM [IC50]
Inhibitor
8297
 4.4 µM [IC50]
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
499 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/30865315/
75 mg single, oral
dose: 75 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SOLRIAMFETOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
5273 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/30865315/
75 mg single, oral
dose: 75 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SOLRIAMFETOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
7.6 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/30865315/
75 mg single, oral
dose: 75 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SOLRIAMFETOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Other AEs: Decreased appetite, Insomnia...
Other AEs:
Decreased appetite (9%)
Insomnia (5%)
Anxiety (6%)
Headache (16%)
Palpitations (2%)
Nausea (7%)
Dry mouth (4%)
Constipation (3%)
Agitation (<2%)
Bruxism (<2%)
Irritability (<2%)
Cough (<2%)
Hyperhidrosis (<2%)
Feeling jittery (<2%)
Thirst (<2%)
Chest discomfort (<2%)
Chest pain (<2%)
Weight decreased (<2%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Disc. AE: Anxiety, Palpitations...
Other AEs: Headache, Nausea...
AEs leading to
discontinuation/dose reduction:
Anxiety (0.5%)
Palpitations (0.5%)
Restlessness (0.5%)
Other AEs:
Headache (13%)
Nausea (9%)
Decreased appetite (8%)
Anxiety (7%)
Dry mouth (4%)
Diarrhea (5%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Other AEs: Headache, Nausea...
Other AEs:
Headache (7%)
Nausea (7%)
Decreased appetite (2%)
Anxiety (2%)
Dry mouth (2%)
Diarrhea (2%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Other AEs: Headache, Nausea...
Other AEs:
Headache (9%)
Nausea (5%)
Decreased appetite (7%)
Anxiety (3%)
Dry mouth (3%)
Diarrhea (4%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Other AEs: Decreased appetite, Anxiety...
Other AEs:
Decreased appetite (6%)
Anxiety (4%)
Irritability (3%)
Dizziness (2%)
Palpitations (3%)
Nausea (8%)
Diarrhea (4%)
Abdominal pain (3%)
Dry mouth (3%)
Feeling jittery (3%)
Chest discomfort (2%)
Hyperhidrosis (2%)
Bruxism (<2%)
Restlessness (<2%)
Disturbance in attention (<2%)
Tremor (<2%)
Cough (<2%)
Dyspnea (<2%)
Constipation (<2%)
Vomiting (<2%)
Weight decreased (<2%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 396
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 396
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Other AEs: Blood pressure systolic increased, Blood pressure diastolic increased...
Other AEs:
Blood pressure systolic increased
Blood pressure diastolic increased
Heart rate increased
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Other AEs: Insomnia, Headache...
Other AEs:
Insomnia (grade 1, 21.9%)
Headache (grade 1, 15.6%)
Hypervigilance (grade 1, 9.4%)
Decreased appetite (grade 1, 9.4%)
Nausea (grade 1, 9.4%)
Insomnia (grade 1, 21.9%)
Headache (grade 1, 12.5%)
Hypervigilance (grade 1, 12.5%)
Decreased appetite (grade 1, 9.4%)
Nausea (grade 1, 6.3%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Disc. AE: Blood pressure increased, Nervousness...
Other AEs: Hypervigilance, Elevated mood...
AEs leading to
discontinuation/dose reduction:
Blood pressure increased (grade 1, 2.4%)
Nervousness (grade 1, 2.4%)
Other AEs:
Hypervigilance (42.9%)
Elevated mood (23.8%)
Dry mouth (21.4%)
Nausea (21.4%)
Feeling of relaxation (19%)
Decreased appetite (19%)
Hyperhidrosis (19%)
Insomnia (16.7%)
Headache (14.3%)
Restlessness (14.3%)
Palpitations (11.9%)
Paresthesia (7.1%)
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
150 mg 1 times / day multiple, oral (mean)
Studied dose
Dose: 150 mg, 1 times / day
Route: oral
Route: multiple
Dose: 150 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
unhealthy
n = 417
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Sex: M+F
Population Size: 417
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
Disc. AE: Blood pressure increased, Hypertension...
AEs leading to
discontinuation/dose reduction:
Blood pressure increased (0.48%)
Hypertension (0.24%)
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
AEs

AEs

AESignificanceDosePopulation
Headache 16%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Palpitations 2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Constipation 3%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dry mouth 4%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Insomnia 5%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Anxiety 6%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Nausea 7%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Decreased appetite 9%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Agitation <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Bruxism <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Chest discomfort <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Chest pain <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Cough <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Feeling jittery <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Hyperhidrosis <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Irritability <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Thirst <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Weight decreased <2%
112.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 112.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 112.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 161
Health Status: unhealthy
Condition: narcolepsy
Age Group: 18 to 75 years
Sex: M+F
Population Size: 161
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Anxiety 0.5%
Disc. AE
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Palpitations 0.5%
Disc. AE
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Restlessness 0.5%
Disc. AE
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Headache 13%
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dry mouth 4%
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Diarrhea 5%
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Anxiety 7%
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Decreased appetite 8%
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Nausea 9%
150 mg 1 times / day steady, oral (mean)
Recommended
Dose: 150 mg, 1 times / day
Route: oral
Route: steady
Dose: 150 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 218
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 218
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Anxiety 2%
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Decreased appetite 2%
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Diarrhea 2%
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dry mouth 2%
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Headache 7%
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Nausea 7%
37.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 37.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 37.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 58
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 58
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Anxiety 3%
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dry mouth 3%
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Diarrhea 4%
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Nausea 5%
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Decreased appetite 7%
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Headache 9%
75 mg 1 times / day steady, oral (mean)
Recommended
Dose: 75 mg, 1 times / day
Route: oral
Route: steady
Dose: 75 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 120
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 120
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Chest discomfort 2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dizziness 2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Hyperhidrosis 2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Abdominal pain 3%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dry mouth 3%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Feeling jittery 3%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Irritability 3%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Palpitations 3%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Anxiety 4%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Diarrhea 4%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Decreased appetite 6%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Nausea 8%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Bruxism <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Constipation <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Cough <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Disturbance in attention <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Dyspnea <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Restlessness <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Tremor <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Vomiting <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Weight decreased <2%
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 235
Health Status: unhealthy
Condition: obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 235
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Blood pressure diastolic increased
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 396
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 396
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Blood pressure systolic increased
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 396
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 396
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Heart rate increased
87.5 mg 1 times / day steady, oral (mean)
Recommended
Dose: 87.5 mg, 1 times / day
Route: oral
Route: steady
Dose: 87.5 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
unhealthy, 18 to 75 years
n = 396
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Age Group: 18 to 75 years
Sex: M+F
Population Size: 396
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211230s000lbl.pdf
Headache grade 1, 12.5%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Hypervigilance grade 1, 12.5%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Headache grade 1, 15.6%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Insomnia grade 1, 21.9%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Insomnia grade 1, 21.9%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Nausea grade 1, 6.3%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Decreased appetite grade 1, 9.4%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Decreased appetite grade 1, 9.4%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Hypervigilance grade 1, 9.4%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Nausea grade 1, 9.4%
300 mg 1 times / day single, oral
Studied dose
Dose: 300 mg, 1 times / day
Route: oral
Route: single
Dose: 300 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
healthy, 19 to 54 years
n = 32
Health Status: healthy
Age Group: 19 to 54 years
Sex: M+F
Population Size: 32
Sources:
https://pubmed.ncbi.nlm.nih.gov/30598342/
Palpitations 11.9%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Headache 14.3%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Restlessness 14.3%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Insomnia 16.7%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Decreased appetite 19%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Feeling of relaxation 19%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Hyperhidrosis 19%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Dry mouth 21.4%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Nausea 21.4%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Elevated mood 23.8%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Hypervigilance 42.9%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Paresthesia 7.1%
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Blood pressure increased grade 1, 2.4%
Disc. AE
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Nervousness grade 1, 2.4%
Disc. AE
1200 mg 1 times / day single, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: single
Dose: 1200 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
healthy, mean age 29.3 years
n = 42
Health Status: healthy
Age Group: mean age 29.3 years
Sex: M
Population Size: 42
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
https://pubmed.ncbi.nlm.nih.gov/30269642/
Hypertension 0.24%
Disc. AE
150 mg 1 times / day multiple, oral (mean)
Studied dose
Dose: 150 mg, 1 times / day
Route: oral
Route: multiple
Dose: 150 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
unhealthy
n = 417
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Sex: M+F
Population Size: 417
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
Blood pressure increased 0.48%
Disc. AE
150 mg 1 times / day multiple, oral (mean)
Studied dose
Dose: 150 mg, 1 times / day
Route: oral
Route: multiple
Dose: 150 mg, 1 times / day
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
unhealthy
n = 417
Health Status: unhealthy
Condition: narcolepsy | obstructive sleep apnea
Sex: M+F
Population Size: 417
Sources:
https://www.ema.europa.eu/en/documents/assessment-report/sunosi-epar-public-assessment-report_en.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1767
inhibitor
1852
inhibitor
1612

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1524

CYP2A6
707

CYP2B6
810

CYP2C8
911

CYP2C19
1478

CYP2E1
882

CYP3A4/5
278

UGT
35

P-gp
1461

BCRP
699

OATP1B1
788

OATP1B3
706

OAT1
599

OAT3
642

OCT1
512

MATE2
263

OCTN1
29

OCTN2
66

OCT2
647

MATE1
306

UGT1A
3

UGT2B7
146
P-gp
1537

BCRP
561

OATP1B1
406

OATP1B3
350

OAT1
326

OAT3
339
CYP1A2
701

CYP2B6
547

CYP3A4/5
124

UGT
29
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
BCRP
773
 no
CYP1A2
1692
 no
CYP1A2
1692
 no
CYP2A6
739
 no
CYP2B6
1001
 no
CYP2B6
1001
 no
CYP2C19
1553
 no
CYP2C8
965
 no
CYP2C9
1819
 no
CYP2E1
970
 no
CYP3A4/5
335
 no
CYP3A4/5
335
 no
MATE2
263
 no
OAT1
603
 no
OAT3
644
 no
OATP1B1
803
 no
OATP1B3
715
 no
OCT1
543
 no
OCTN1
29
 no
OCTN2
71
 no
P-gp
1650
 no
UGT
59
 no
UGT
59
 no
UGT1A
5
 no
UGT2B7
157
 no
OCT2
648
 weak [IC50 146 uM]
MATE1
308
 weak [IC50 211 uM]
CYP2D6
1891
 weak [IC50 360 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
BCRP
561
 no
OAT1
326
 no
OAT3
339
 no
OATP1B1
406
 no
OATP1B3
350
 no
P-gp
1537
 no
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1647
Sourcing

Sourcing

Vendor/AggregatorIDURL
1PlusChem LLC
1P01C3BA
A2B Chem
AW42982
AA Blocks
AA01C2RU
AChemBlock
Q69522
Chem Scene
CS-0031486
http://www.chemscene.com/178429-62-4.html
ChemShuttle
139041
Chemspace
CSSB00041015464
https://chem-space.com/CSSB00041015464
Enamine
BBV-44122269
Enamine
BBV-77772338
Enamine
EN300-253107
Hairui
R2CQ017
KeyOrganics
CS-2577
MedChem Express
HY-109043
https://www.medchemexpress.com/solriamfetol.html
MolPort
MolPort-039-241-646
MolPort
MolPort-046-793-373
MolPort
MolPort-047-156-022
Molnova
M12688
MuseChem
I009552
Smolecule
S543563
http://www.smolecule.com/products/s543563
Smolecule
S727641
https://www.smolecule.com/products/s727641
THE BioTek
bt-284158
https://www.thebiotek.com/product/inhibitors/bt-284158
THE BioTek
bt-386716
https://www.thebiotek.com/product/others/bt-386716
Toronto Research Chemicals
S676775
ZINC
ZINC000034278783
http://zinc15.docking.org/substances/ZINC000034278783
eMolecules
222563444
eMolecules
303230315
eMolecules
67911099
mcule
MCULE-3233675360
PubMed

PubMed

TitleDatePubMed
Effect of oral JZP-110 (ADX-N05) treatment on wakefulness and sleepiness in adults with narcolepsy.
2015 Sep
Effect of Oral JZP-110 (ADX-N05) on Wakefulness and Sleepiness in Adults with Narcolepsy: A Phase 2b Study.
2016 Jul 1
New developments in the management of narcolepsy.
2017

Sample Use Guides

In Vivo Use Guide
The dual-acting dopamine and norepinephrine reuptake inhibitor is approved for narcolepsy in once-daily 75 mg and 150 mg doses, and in obstructive sleep apnea in once-daily 37.5 mg, 75 mg, and 150 mg doses.
Route of Administration: Oral
In Vitro Use Guide
Solriamfetol binds to the dopamine transporter and norepinephrine transporter with low affinity (Ki=14.2 uM and 3.7 uM, respectively), and inhibits the reuptake of dopamine and norepinephrine with low potency (IC50 =2.9 uM and 4.4 uM, respectively). Solriamfetol has no appreciable binding affinity for the serotonin transporter (Ki=81.5 uM) and does not inhibit serotonin reuptake (IC50 > 100 uM).
Name Type Language
Solriamfetol Hydrochloride
USAN  
Official Name English
Solriamfetol hydrochloride [WHO-DD]
Common Name English
ADX-N05 HYDROCHLORIDE
Code English
ADX-N-05 HYDROCHLORIDE
Code English
YKP-10A HYDROCHLORIDE
Code English
SOLRIAMFETOL HYDROCHLORIDE [ORANGE BOOK]
Common Name English
(2R)-2-Amino-3-phenylpropyl carbamate, monohydrochloride
Systematic Name English
BENZENEPROPANOL, .BETA.-AMINO-, 1-CARBAMATE, HYDROCHLORIDE (1:1), (.BETA.R)-
Systematic Name English
SKL-N-05 HYDROCHLORIDE
Code English
R-228060 HYDROCHLORIDE
Code English
SOLRIAMFETOL HYDROCHLORIDE [USAN]
Common Name English
JZP-110 HYDROCHLORIDE
Code English
SOLRIAMFETOL HYDROCHLORIDE [MI]
Common Name English
(R)-(+)-2-AMINO-1-CARBAMOYLOXY-3-PHENYLPROPANE HYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 375112
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
Code System Code Type Description
RXCUI
2121750
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
NCI_THESAURUS
C170379
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
EPA CompTox
DTXSID101027927
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
MERCK INDEX
m12132
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
MESH
C470510
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
FDA UNII
K7RO88SP7A
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
USAN
EF-114
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
DRUG BANK
DBSALT002865
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
PUBCHEM
67583702
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
CAS
178429-65-7
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
SMS_ID
100000180154
Created by admin on Fri Dec 15 15:28:54 GMT 2023 , Edited by admin on Fri Dec 15 15:28:54 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of Solriamfetol
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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