Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H7NO.C6H8O7 |
Molecular Weight | 337.2815 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=CC2=C1N=CC=C2.OC(=O)CC(O)(CC(O)=O)C(O)=O
InChI
InChIKey=GTOQWWQKBBZILU-UHFFFAOYSA-N
InChI=1S/C9H7NO.C6H8O7/c11-8-5-1-3-7-4-2-6-10-9(7)8;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-6,11H;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
DescriptionSources: http://drugcentral.org/drugcard/3290/viewCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/25935783 |
https://www.ams.usda.gov/sites/default/files/media/Hydroxyquinoline%20Sulfate%20TR.pdf |
https://www.ncbi.nlm.nih.gov/pubmed/13960592
Sources: http://drugcentral.org/drugcard/3290/view
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/25935783 |
https://www.ams.usda.gov/sites/default/files/media/Hydroxyquinoline%20Sulfate%20TR.pdf |
https://www.ncbi.nlm.nih.gov/pubmed/13960592
8-Hydroxyquinoline is is a heterocyclic phenol, exhibiting antiseptic, disinfectant and pesticide properties. It is used to prevent and treat vaginal bacterial infections, but the efficacy was not proven in clinical trial. 8-Hydroxyquinoline is used in over-the-counter remedies for diaper rash and oral health care. Its use for veterinary treatment of bacterial an skin infections is not approved by FDA. 8-Hydroxyquinoline acts by inhibition of RNA synthesis and DNA replication by chelating the dissociable cations Mn2+ and Mg2+.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0030026 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13960592 |
|||
Target ID: GO:0010960 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13960592 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | TRIMOSAN Approved UseIncreasing and maintaining vaginal acidity in combination with other medicines. |
|||
Primary | Unknown Approved UseUnknown |
|||
Curative | Unknown Approved Use8-Hydroxyquinoline was used in veterinary for treatment of poultry diseases, for treatment of intestinal infections caused by bacteria or protozoa, for bacterial and fungal skin infections. |
Sample Use Guides
Relagard vaginal gel: attach the enclosed applicator to the tube of Relagard by screwing it on clockwise. Squeeze the tube to force the contents into the barrel until the applicator is filled. Detach the applicator from the tube and gently insert it into the vagina as far as it will comfortably go. Press the plunger and deposit the medication until the barrel of the applicator is emptied. For treatment of bacterial and protozoal infections is administered to cattle topically or orally.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/353531
Complete inhibition of sporulation was observed in two strains of Saccharomyces cerevisiae to which 8-hydroxyquinoline was added at a final concentration of 5 microgram/ml during the initial 4 to 6 h of sporulation. The cells were most sensitive to the inhibitor during 4 to 6 interval beginning at approximately 2 h (T2). Its addition during that interval resulted in 70 to 80% lethality in strain 4579 and about 40% in API at T24. When present from T0 onward, 5 microgram/ml of 8-hydroxyquinoline severely inhibited premeiotic DNA replication and reduced the frequency of intragenic recombination at the ade 2 and leu 2 loci by 70 and 100%, respectively, relative to control cultures which did not have the inhibitor present.
Name | Type | Language | ||
---|---|---|---|---|
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Code | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
EPA PESTICIDE CODE |
59802
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
102928-43-8
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
NON-SPECIFIC STOICHIOMETRY | |||
|
K522O2O40B
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
PRIMARY | |||
|
DBSALT002680
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
PRIMARY | |||
|
205-136-6
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
PRIMARY | |||
|
DTXSID1040326
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
PRIMARY | |||
|
61080
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
PRIMARY | |||
|
134-30-5
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
PRIMARY | |||
|
52216-56-5
Created by
admin on Sat Dec 16 09:10:58 GMT 2023 , Edited by admin on Sat Dec 16 09:10:58 GMT 2023
|
ALTERNATIVE |
PARENT (SALT/SOLVATE)
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD