Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H21NO |
| Molecular Weight | 243.344 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CCCC[C@@]13CCN[C@@H]2CC4=CC=C(O)C=C34
InChI
InChIKey=IYNWSQDZXMGGGI-NUEKZKHPSA-N
InChI=1S/C16H21NO/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12/h4-5,10,13,15,17-18H,1-3,6-9H2/t13-,15+,16+/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. | 2001 Apr 15 |
|
| Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? | 2001 Nov |
|
| A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. | 2002 Aug 22 |
|
| The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. | 2002 Jul 26 |
|
| Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel. | 2003 Jan-Feb |
|
| New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. | 2003 Mar 7 |
|
| Determination of dextromethorphan and its metabolites in rat serum by liquid-liquid extraction and liquid chromatography with fluorescence detection. | 2003 May 25 |
|
| Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism. | 2004 Dec 1 |
|
| Effect of methamphetamine on the pharmacokinetics of dextromethorphan and midazolam in rats. | 2005 Jul-Sep |
|
| Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers. | 2005 Jun |
|
| 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. | 2005 Mar |
|
| Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. | 2006 Jul |
|
| Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. | 2008 Jan |
|
| Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM). | 2008 Jul |
|
| Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism. | 2009 Feb |
|
| Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. | 2009 Jul |
|
| A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. | 2009 Nov |
|
| Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. | 2011 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Code | English | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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DEA NO. |
9634
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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SUB09375MIG
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY | |||
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100000083600
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY | |||
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873
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY | |||
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NORLEVORPHANOL
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY | Norlevorphanol is an opioid analgesic of the morphinan class. It was never marketed. | ||
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C054116
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY | |||
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216-236-4
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5463854
Created by
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PRIMARY | |||
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1531-12-0
Created by
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PRIMARY | |||
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C170233
Created by
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CHEMBL2105152
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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m8066
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY | Merck Index | ||
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IL94262N7K
Created by
admin on Fri Dec 15 19:29:27 UTC 2023 , Edited by admin on Fri Dec 15 19:29:27 UTC 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
