EMBRAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H22BrNO
Molecular Weight	348.277
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCOC(C)(C1=CC=CC=C1)C2=CC=C(Br)C=C2

InChI

InChIKey=URSRSKSNFPUKGH-UHFFFAOYSA-N

InChI=1S/C18H22BrNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3

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Description
Sources: https://www.medindia.net/doctors/drug_information/embramine.htm | https://www.drugs.com/international/embramine.html | https://www.ncbi.nlm.nih.gov/pubmed/7976789

Embramine or mebrophenhydramine is an antiallergic agent. Embramine is a histamine H₁-receptor antagonist exerting anticholinergic activity. It may inhibit stimulated platelet functions by inhibiting phospholipase A2. It is prescribed for severe allergic conditions.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7758143	Antagonist 2778

PubMed

Title	Date	PubMed
Pharmacological intervention with platelet phospholipase A2.	2001	11802290
Cationic amphiphilic drugs and platelet phospholipase A(2) (cPLA(2)).	2002 Feb 15	12031829
Titrimetric and spectrophotometric assay of some antihistamines through the determination of the chloride of their hydrochlorides.	2002 Jan	11902650
H(1)- antihistamines and activated blood platelets.	2006 Apr	16547813

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 25mg, every 4 to 6 hours. Max: 150mg.

Route of Administration: Oral

Name

Type

Language

EMBRAMINE

Official Name

English

embramine [INN]

Common Name

English

Embramine [WHO-DD]

Common Name

English

EMBRAMINE [MI]

Common Name

English

2-((P-BROMO-.ALPHA.-METHYL-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578