ICODULINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N2OS
Molecular Weight	206.264
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(O)=C(NC2=NC=CS2)C=C1

InChI

InChIKey=UTHOTQDPKFKRKG-UHFFFAOYSA-N

InChI=1S/C10H10N2OS/c1-7-2-3-8(9(13)6-7)12-10-11-4-5-14-10/h2-6,13H,1H3,(H,11,12)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2514693 | https://adisinsight.springer.com/drugs/800003340 | https://www.ncbi.nlm.nih.gov/pubmed/2514693

Icoduline (previously known as CBS-113 A) is a dual inhibitor of 5-lipoxygenase and cyclo-oxygenase with anti-inflammatory properties. This drug was potentially useful in ophthalmology and as an alternative to glucocorticoids. In addition, icoduline was useful to treat skin disorders. The drug participated in the clinical trial for eye disorders in France; however, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of lipoxygenase inhibitors on the arachidonic acid cascade in the rabbit cornea after injury.	1988 Spring	3139810
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 1st communication: in vitro studies.	1989 Oct	2514692
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 2nd communication: anti-inflammatory activity.	1989 Oct	2514693
Electrochemical oxidation of CBS-113 A, a new anti-inflammatory drug: applicability to liquid chromatography-electrochemical detection.	1995 Aug	8573639

Patents

Sample Use Guides

In Vivo Use Guide

0.1%

Route of Administration: Topical

Name

Type

Language

ICODULINE

Official Name

English

icoduline [INN]

Common Name

English

6-(2-THIAZOLYLAMINO)-M-CRESOL

Systematic Name

English

ICODULINUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257