Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H31F6N7O2.2ClH |
| Molecular Weight | 708.525 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F
InChI
InChIKey=QBQHUKKLUVZUBC-MQWQBNKOSA-N
InChI=1S/C30H31F6N7O2.2ClH/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41;;/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40);2*1H/t23-;;/m1../s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. | 2001 |
|
| Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid status. | 2001 |
|
| Role of thyroid hormones in the maturation and organisation of rat barrel cortex. | 2001 |
|
| The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. | 2001 |
|
| Coexistence of Graves' disease and struma ovarii: case report and literature review. | 2001 Apr |
|
| Morning granulocytopenia in a case of Graves' disease. | 2001 Apr |
|
| A case of pulmonary metastatic thyroid cancer complicated with Graves' disease. | 2001 Apr |
|
| Graves' disease presenting as elephantiasic pretibial myxedema and nodules of the hands. | 2001 Apr |
|
| [Graves-Basedow disease associated with unusual variation of thyroid papillary carcinoma: a clinical case]. | 2001 Apr-Jun |
|
| Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography. | 2001 Aug |
|
| Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13. | 2001 Aug |
|
| Massive plasmocytosis due to methimazole-induced bone marrow toxicity. | 2001 Aug |
|
| [Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism]. | 2001 Aug 15 |
|
| Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats. | 2001 Dec |
|
| Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver. | 2001 Dec |
|
| Impact of hyperthyroidism and its correction on vascular reactivity in humans. | 2001 Dec 18 |
|
| Interplay of pregnancy, lactation, and hyperthyroidism leading to severe osteoporosis in a young woman. | 2001 Jul-Aug |
|
| Cross-bridge and calcium behavior in ferret papillary muscle in different thyroid states. | 2001 Jun |
|
| Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter. | 2001 Jun |
|
| Influence of hypothyroid state on 45Ca(2+) influx and sensitivity of rat uterus to nifedipine and diltiazem. | 2001 Jun 15 |
|
| [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. | 2001 Mar 10 |
|
| [Efficacy of quinagolide in the treatment of a patient with hypophyseal resistance to thyroid hormones]. | 2001 May |
|
| Methimazole-induced pulmonary hemorrhage associated with antimyeloperoxidase-antineutrophil cytoplasmic antibody: a case report. | 2001 Nov |
|
| Influence of nicotinamide on the radiosensitivity of normal and goitrous thyroid in the rat. | 2001 Nov |
|
| Adverse effects of prenatal methimazole exposure. | 2001 Nov |
|
| Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. | 2001 Nov |
|
| Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. | 2001 Nov |
|
| Different role of insulin in GLUT-1 and -4 regulation in heart and skeletal muscle during perinatal hypothyroidism. | 2001 Nov |
|
| Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. | 2001 Nov 15 |
|
| Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram. | 2001 Oct |
|
| Suppression of serum TSH by Graves' Ig: evidence for a functional pituitary TSH receptor. | 2001 Oct |
|
| Selective effect of hypothyroidism on expression of myelin markers during development. | 2001 Oct 15 |
|
| Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss. | 2001 Oct 19 |
|
| Antithyroid drugs as a factor influencing the outcome of radioiodine therapy in Graves' disease and toxic nodular goitre? | 2001 Sep |
|
| Effect of losartan on sodium appetite of hypothyroid rats subjected to water and sodium depletion and water, sodium and food deprivation. | 2001 Sep |
|
| Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids. | 2001 Sep |
|
| The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. | 2001 Sep-Oct |
|
| Dermatomyositis and Graves' disease. | 2001 Sep-Oct |
|
| Severe embryopathy and exposure to methimazole in early pregnancy. | 2002 Feb |
|
| Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced involution. | 2002 Feb |
|
| Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats. | 2002 Feb |
|
| Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment. | 2002 Feb |
|
| Depigmentation of brown Guinea pig skin by topical application of methimazole. | 2002 Jan |
|
| Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats. | 2002 Jan |
|
| Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil. | 2002 Jan |
|
| Methimazole-induced asthma? | 2002 Jan |
|
| Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. | 2002 Jan |
|
| Polarization IR spectra of model crystals containing cyclic N-H...S bonded dimers: 2-mercaptothiazoline and 2-mercapto-1-methylimidazole. | 2002 Jan 15 |
|
| Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. | 2002 Jan 25 |
|
| Subclinical hyperthyroidism. | 2002 Jan 3 |
Patents
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Systematic Name | English | ||
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Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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H5KHP6OQ62
Created by
admin on Sat Dec 16 11:03:30 GMT 2023 , Edited by admin on Sat Dec 16 11:03:30 GMT 2023
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PRIMARY | |||
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393183-40-9
Created by
admin on Sat Dec 16 11:03:30 GMT 2023 , Edited by admin on Sat Dec 16 11:03:30 GMT 2023
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PRIMARY | |||
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16109663
Created by
admin on Sat Dec 16 11:03:30 GMT 2023 , Edited by admin on Sat Dec 16 11:03:30 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
