Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C30H31F6N7O2 |
Molecular Weight | 635.6033 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F
InChI
InChIKey=SXASYKWUZQHLET-HSZRJFAPSA-N
InChI=1S/C30H31F6N7O2/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40)/t23-/m1/s1
Molecular Formula | C30H31F6N7O2 |
Molecular Weight | 635.6033 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
PubMed
Title | Date | PubMed |
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Ectodermal abnormalities associated with methimazole intrauterine exposure. | 2000 Oct 2 |
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Drug-induced congenital defects: strategies to reduce the incidence. | 2001 |
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Role of thyroid hormones in the maturation and organisation of rat barrel cortex. | 2001 |
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Graves' disease presenting as elephantiasic pretibial myxedema and nodules of the hands. | 2001 Apr |
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[Simultaneous occurrence of Basedow's disease and autoimmune hemolytic anemia]. | 2001 Apr |
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Use of percutaneous ethanol injection for treatment of bilateral hyperplastic thyroid nodules in cats. | 2001 Apr 15 |
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Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography. | 2001 Aug |
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Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13. | 2001 Aug |
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The effect of methimazole pretreatment on the efficacy of radioactive iodine therapy in Graves' hyperthyroidism: one-year follow-up of a prospective, randomized study. | 2001 Aug |
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[Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism]. | 2001 Aug 15 |
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Clinical practice. Subclinical hyperthyroidism. | 2001 Aug 16 |
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Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats. | 2001 Dec |
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The systolic function of the left ventricle of the heart in patients with hyperthyroidism during therapy. | 2001 Feb |
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Hyperthyroid dementia: clinicoradiological findings and response to treatment. | 2001 Feb 15 |
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Impact of neonatal hypothyroidism on Leydig cell number, plasma, and testicular interstitial fluid sex steroids concentration. | 2001 Feb-May |
|
Interplay of pregnancy, lactation, and hyperthyroidism leading to severe osteoporosis in a young woman. | 2001 Jul-Aug |
|
Cross-bridge and calcium behavior in ferret papillary muscle in different thyroid states. | 2001 Jun |
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Purification and catalytic properties of the chlorophenol 4-monooxygenase from Burkholderia cepacia strain AC1100. | 2001 Jun 11 |
|
[A thyrotoxic myopathy accompanied with unusual muscle symptoms and MRI muscle findings]. | 2001 Mar |
|
[Efficacy of quinagolide in the treatment of a patient with hypophyseal resistance to thyroid hormones]. | 2001 May |
|
Clinical, endocrinological and radiography features in a child with McCune-Albright syndrome and pituitary adenoma. | 2001 May |
|
Method for the analysis of thyreostats in meat tissue using gas chromatography with nitrogen phosphorus detection and tandem mass spectrometric confirmation. | 2001 May |
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Influence of nicotinamide on the radiosensitivity of normal and goitrous thyroid in the rat. | 2001 Nov |
|
Adverse effects of prenatal methimazole exposure. | 2001 Nov |
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Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. | 2001 Nov |
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Different role of insulin in GLUT-1 and -4 regulation in heart and skeletal muscle during perinatal hypothyroidism. | 2001 Nov |
|
Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. | 2001 Nov 15 |
|
Thyroid hormones modify susceptibility to lidocaine-kindling in rats. | 2001 Oct 19 |
|
Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. | 2001 Sep |
|
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids. | 2001 Sep |
|
Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to Graves' disease. | 2001 Sep-Oct |
|
Methimazole-induced asthma? | 2002 Jan |
|
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. | 2002 Jan |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:03:30 GMT 2023
by
admin
on
Sat Dec 16 11:03:30 GMT 2023
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Record UNII |
WPL66843QN
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Record Status |
Validated (UNII)
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Record Version |
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-
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Common Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
Code System | Code | Type | Description | ||
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(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Created by
admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
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11635932
Created by
admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
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WPL66843QN
Created by
admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
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393101-98-9
Created by
admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
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PRIMARY |
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TARGET -> INHIBITOR |
INHIBITOR
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |