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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H31F6N7O2
Molecular Weight 635.6033
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SLV-317 FREE BASE

SMILES

FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F

InChI

InChIKey=SXASYKWUZQHLET-HSZRJFAPSA-N
InChI=1S/C30H31F6N7O2/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40)/t23-/m1/s1

HIDE SMILES / InChI
Molecular Formula C30H31F6N7O2
Molecular Weight 635.6033
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
127998
PubMed

PubMed

TitleDatePubMed
Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse.
2001
Drug-induced congenital defects: strategies to reduce the incidence.
2001
Role of thyroid hormones in the maturation and organisation of rat barrel cortex.
2001
Coexistence of Graves' disease and struma ovarii: case report and literature review.
2001 Apr
Graves' disease presenting as elephantiasic pretibial myxedema and nodules of the hands.
2001 Apr
[Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism].
2001 Aug 15
Antioxidants in the treatment of Graves disease.
2001 Feb
Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol.
2001 Feb
Side-effects of iodized oil administration in patients with simple goiter.
2001 Feb
[Arthritis and antithyroid agents].
2001 Feb 28
Impact of neonatal hypothyroidism on Leydig cell number, plasma, and testicular interstitial fluid sex steroids concentration.
2001 Feb-May
Basedow's disease and chronic ulcerative colitis: a case report and review of the Japanese literature.
2001 Jan
Effect of altered thyroid status on neurotrophin gene expression during postnatal development of the mouse cerebellum.
2001 Mar
Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism.
2001 Mar
[A thyrotoxic myopathy accompanied with unusual muscle symptoms and MRI muscle findings].
2001 Mar
Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment.
2001 Mar
Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging.
2001 Nov
Radioiodine and Graves' ophthalmopathy reconsidered.
2001 Nov
Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus.
2001 Nov 26
Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment.
2002 Feb
Depigmentation of brown Guinea pig skin by topical application of methimazole.
2002 Jan
Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats.
2002 Jan
Subclinical hyperthyroidism.
2002 Jan 3
Patents

Patents

03935209
7
03996238
3
04005202
3
04038392
3
04400509
5
04443435
3
04496720
4
04596870
3
04678789
3
04705791
4
04973599
4
05256675
4
05369107
5
05405861
6
05484774
5
05616579
6
05641788
4
05670453
5
05672567
3
05683989
7
05821246
5
05866572
3
05948782
4
05962458
5
06071921
9
06150377
3
06172057
6
06197791
3
06258951
3
06288086
3
06294552
3
Substance Class Chemical
Created
by admin
on Sun Dec 18 06:40:22 UTC 2022
Edited
by admin
on Sun Dec 18 06:40:22 UTC 2022
Record UNII
WPL66843QN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SLV-317 FREE BASE
Common Name English
METHANONE, (3,5-BIS(TRIFLUOROMETHYL)PHENYL)((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(4-MORPHOLINYLMETHYL)-2H-1,2,3-TRIAZOL-4-YL)METHYL)-1-PIPERAZINYL)-
Systematic Name English
SLV-317(FREE BASE)
Code English
PIPERAZINE, 1-(3,5-BIS(TRIFLUOROMETHYL)BENZOYL)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(4-MORPHOLINYLMETHYL)-2H-1,2,3-TRIAZOL-4-YL)METHYL)-, (2R)-
Systematic Name English
(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Systematic Name English
Code System Code Type Description
MANUFACTURER PRODUCT INFORMATION
(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Created by admin on Sun Dec 18 06:40:23 UTC 2022 , Edited by admin on Sun Dec 18 06:40:23 UTC 2022
PRIMARY
PUBCHEM
11635932
Created by admin on Sun Dec 18 06:40:23 UTC 2022 , Edited by admin on Sun Dec 18 06:40:23 UTC 2022
PRIMARY
FDA UNII
WPL66843QN
Created by admin on Sun Dec 18 06:40:23 UTC 2022 , Edited by admin on Sun Dec 18 06:40:23 UTC 2022
PRIMARY
CAS
393101-98-9
Created by admin on Sun Dec 18 06:40:23 UTC 2022 , Edited by admin on Sun Dec 18 06:40:23 UTC 2022
PRIMARY
Related Record Type Details
SUBSTANCE-P RECEPTOR
TARGET -> INHIBITOR
INHIBITOR
Structure of SLV-317
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of SLV-317 FREE BASE
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