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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H31F6N7O2
Molecular Weight 635.6033
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SLV-317 FREE BASE

SMILES

FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F

InChI

InChIKey=SXASYKWUZQHLET-HSZRJFAPSA-N
InChI=1S/C30H31F6N7O2/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40)/t23-/m1/s1

HIDE SMILES / InChI

Molecular Formula C30H31F6N7O2
Molecular Weight 635.6033
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
Ectodermal abnormalities associated with methimazole intrauterine exposure.
2000 Oct 2
Drug-induced congenital defects: strategies to reduce the incidence.
2001
Role of thyroid hormones in the maturation and organisation of rat barrel cortex.
2001
Graves' disease presenting as elephantiasic pretibial myxedema and nodules of the hands.
2001 Apr
[Simultaneous occurrence of Basedow's disease and autoimmune hemolytic anemia].
2001 Apr
Use of percutaneous ethanol injection for treatment of bilateral hyperplastic thyroid nodules in cats.
2001 Apr 15
Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography.
2001 Aug
Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13.
2001 Aug
The effect of methimazole pretreatment on the efficacy of radioactive iodine therapy in Graves' hyperthyroidism: one-year follow-up of a prospective, randomized study.
2001 Aug
[Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism].
2001 Aug 15
Clinical practice. Subclinical hyperthyroidism.
2001 Aug 16
Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats.
2001 Dec
The systolic function of the left ventricle of the heart in patients with hyperthyroidism during therapy.
2001 Feb
Hyperthyroid dementia: clinicoradiological findings and response to treatment.
2001 Feb 15
Impact of neonatal hypothyroidism on Leydig cell number, plasma, and testicular interstitial fluid sex steroids concentration.
2001 Feb-May
Interplay of pregnancy, lactation, and hyperthyroidism leading to severe osteoporosis in a young woman.
2001 Jul-Aug
Cross-bridge and calcium behavior in ferret papillary muscle in different thyroid states.
2001 Jun
Purification and catalytic properties of the chlorophenol 4-monooxygenase from Burkholderia cepacia strain AC1100.
2001 Jun 11
[A thyrotoxic myopathy accompanied with unusual muscle symptoms and MRI muscle findings].
2001 Mar
[Efficacy of quinagolide in the treatment of a patient with hypophyseal resistance to thyroid hormones].
2001 May
Clinical, endocrinological and radiography features in a child with McCune-Albright syndrome and pituitary adenoma.
2001 May
Method for the analysis of thyreostats in meat tissue using gas chromatography with nitrogen phosphorus detection and tandem mass spectrometric confirmation.
2001 May
Influence of nicotinamide on the radiosensitivity of normal and goitrous thyroid in the rat.
2001 Nov
Adverse effects of prenatal methimazole exposure.
2001 Nov
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
2001 Nov
Different role of insulin in GLUT-1 and -4 regulation in heart and skeletal muscle during perinatal hypothyroidism.
2001 Nov
Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
2001 Nov 15
Thyroid hormones modify susceptibility to lidocaine-kindling in rats.
2001 Oct 19
Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.
2001 Sep
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids.
2001 Sep
Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to Graves' disease.
2001 Sep-Oct
Methimazole-induced asthma?
2002 Jan
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein.
2002 Jan
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:03:30 GMT 2023
Edited
by admin
on Sat Dec 16 11:03:30 GMT 2023
Record UNII
WPL66843QN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SLV-317 FREE BASE
Common Name English
METHANONE, (3,5-BIS(TRIFLUOROMETHYL)PHENYL)((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(4-MORPHOLINYLMETHYL)-2H-1,2,3-TRIAZOL-4-YL)METHYL)-1-PIPERAZINYL)-
Systematic Name English
SLV-317(FREE BASE)
Code English
PIPERAZINE, 1-(3,5-BIS(TRIFLUOROMETHYL)BENZOYL)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(4-MORPHOLINYLMETHYL)-2H-1,2,3-TRIAZOL-4-YL)METHYL)-, (2R)-
Systematic Name English
(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Systematic Name English
Code System Code Type Description
MANUFACTURER PRODUCT INFORMATION
(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
PUBCHEM
11635932
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
FDA UNII
WPL66843QN
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
CAS
393101-98-9
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
INHIBITOR
SALT/SOLVATE -> PARENT
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ACTIVE MOIETY