Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H31F6N7O2 |
| Molecular Weight | 635.6033 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F
InChI
InChIKey=SXASYKWUZQHLET-HSZRJFAPSA-N
InChI=1S/C30H31F6N7O2/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40)/t23-/m1/s1
| Molecular Formula | C30H31F6N7O2 |
| Molecular Weight | 635.6033 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ectodermal abnormalities associated with methimazole intrauterine exposure. | 2000 Oct 2 |
|
| [Ablative therapy for immune hyperthyroidism in patients with ophthalmopathy]. | 2001 |
|
| Coexistence of Graves' disease and struma ovarii: case report and literature review. | 2001 Apr |
|
| Drug-dependent antibodies against the prodrug carbimazole do not react with the metabolite thiamazole. | 2001 Apr 1 |
|
| Use of percutaneous ethanol injection for treatment of bilateral hyperplastic thyroid nodules in cats. | 2001 Apr 15 |
|
| [Graves-Basedow disease associated with unusual variation of thyroid papillary carcinoma: a clinical case]. | 2001 Apr-Jun |
|
| Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13. | 2001 Aug |
|
| The effect of methimazole pretreatment on the efficacy of radioactive iodine therapy in Graves' hyperthyroidism: one-year follow-up of a prospective, randomized study. | 2001 Aug |
|
| [Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism]. | 2001 Aug 15 |
|
| Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats. | 2001 Dec |
|
| Side-effects of iodized oil administration in patients with simple goiter. | 2001 Feb |
|
| Hyperthyroid dementia: clinicoradiological findings and response to treatment. | 2001 Feb 15 |
|
| Impact of neonatal hypothyroidism on Leydig cell number, plasma, and testicular interstitial fluid sex steroids concentration. | 2001 Feb-May |
|
| Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. | 2001 Jul 1 |
|
| Neuronal expression of synaptotagmin-related gene 1 is regulated by thyroid hormone during cerebellar development. | 2001 Jun 15 |
|
| Effect of altered thyroid status on neurotrophin gene expression during postnatal development of the mouse cerebellum. | 2001 Mar |
|
| [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. | 2001 Mar 10 |
|
| Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. | 2001 Nov |
|
| Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. | 2001 Nov |
|
| Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram. | 2001 Oct |
|
| Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss. | 2001 Oct 19 |
|
| Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. | 2001 Sep |
|
| The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. | 2001 Sep-Oct |
|
| Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to Graves' disease. | 2001 Sep-Oct |
|
| Depigmentation of brown Guinea pig skin by topical application of methimazole. | 2002 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:03:30 UTC 2023
by
admin
on
Sat Dec 16 11:03:30 UTC 2023
|
| Record UNII |
WPL66843QN
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Created by
admin on Sat Dec 16 11:03:31 UTC 2023 , Edited by admin on Sat Dec 16 11:03:31 UTC 2023
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11635932
Created by
admin on Sat Dec 16 11:03:31 UTC 2023 , Edited by admin on Sat Dec 16 11:03:31 UTC 2023
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PRIMARY | |||
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WPL66843QN
Created by
admin on Sat Dec 16 11:03:31 UTC 2023 , Edited by admin on Sat Dec 16 11:03:31 UTC 2023
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PRIMARY | |||
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393101-98-9
Created by
admin on Sat Dec 16 11:03:31 UTC 2023 , Edited by admin on Sat Dec 16 11:03:31 UTC 2023
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PRIMARY |
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
