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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H31F6N7O2
Molecular Weight 635.6033
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SLV-317 FREE BASE

SMILES

FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F

InChI

InChIKey=SXASYKWUZQHLET-HSZRJFAPSA-N
InChI=1S/C30H31F6N7O2/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40)/t23-/m1/s1

HIDE SMILES / InChI

Molecular Formula C30H31F6N7O2
Molecular Weight 635.6033
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse.
2001
Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid status.
2001
Drug-induced congenital defects: strategies to reduce the incidence.
2001
Role of thyroid hormones in the maturation and organisation of rat barrel cortex.
2001
[Ablative therapy for immune hyperthyroidism in patients with ophthalmopathy].
2001
The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid.
2001
[Graves-Basedow disease associated with unusual variation of thyroid papillary carcinoma: a clinical case].
2001 Apr-Jun
Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography.
2001 Aug
[Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism].
2001 Aug 15
Clinical practice. Subclinical hyperthyroidism.
2001 Aug 16
Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats.
2001 Dec
Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver.
2001 Dec
Impact of hyperthyroidism and its correction on vascular reactivity in humans.
2001 Dec 18
A case of thyrotoxicosis with pancytopenia.
2001 Jun
[Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs].
2001 Mar 10
Methimazole-induced pulmonary hemorrhage associated with antimyeloperoxidase-antineutrophil cytoplasmic antibody: a case report.
2001 Nov
Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder.
2001 Nov
Influence of nicotinamide on the radiosensitivity of normal and goitrous thyroid in the rat.
2001 Nov
Adverse effects of prenatal methimazole exposure.
2001 Nov
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
2001 Nov
Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging.
2001 Nov
Radioiodine and Graves' ophthalmopathy reconsidered.
2001 Nov
Different role of insulin in GLUT-1 and -4 regulation in heart and skeletal muscle during perinatal hypothyroidism.
2001 Nov
Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
2001 Nov 15
Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus.
2001 Nov 26
Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram.
2001 Oct
Risk of torsades de pointes from oral erythromycin with concomitant carbimazole (methimazole) administration.
2001 Oct
Suppression of serum TSH by Graves' Ig: evidence for a functional pituitary TSH receptor.
2001 Oct
Use of oral cholecystographic agents in the treatment of amiodarone-induced hyperthyroidism.
2001 Oct
Selective effect of hypothyroidism on expression of myelin markers during development.
2001 Oct 15
Thyroid hormones modify susceptibility to lidocaine-kindling in rats.
2001 Oct 19
Antithyroid drugs as a factor influencing the outcome of radioiodine therapy in Graves' disease and toxic nodular goitre?
2001 Sep
Effect of losartan on sodium appetite of hypothyroid rats subjected to water and sodium depletion and water, sodium and food deprivation.
2001 Sep
Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.
2001 Sep
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids.
2001 Sep
The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats.
2001 Sep-Oct
Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to Graves' disease.
2001 Sep-Oct
Dermatomyositis and Graves' disease.
2001 Sep-Oct
Severe embryopathy and exposure to methimazole in early pregnancy.
2002 Feb
Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced involution.
2002 Feb
Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats.
2002 Feb
Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment.
2002 Feb
Depigmentation of brown Guinea pig skin by topical application of methimazole.
2002 Jan
Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats.
2002 Jan
Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil.
2002 Jan
Methimazole-induced asthma?
2002 Jan
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein.
2002 Jan
Polarization IR spectra of model crystals containing cyclic N-H...S bonded dimers: 2-mercaptothiazoline and 2-mercapto-1-methylimidazole.
2002 Jan 15
Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism.
2002 Jan 25
Subclinical hyperthyroidism.
2002 Jan 3
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:03:30 GMT 2023
Edited
by admin
on Sat Dec 16 11:03:30 GMT 2023
Record UNII
WPL66843QN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SLV-317 FREE BASE
Common Name English
METHANONE, (3,5-BIS(TRIFLUOROMETHYL)PHENYL)((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(4-MORPHOLINYLMETHYL)-2H-1,2,3-TRIAZOL-4-YL)METHYL)-1-PIPERAZINYL)-
Systematic Name English
SLV-317(FREE BASE)
Code English
PIPERAZINE, 1-(3,5-BIS(TRIFLUOROMETHYL)BENZOYL)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(4-MORPHOLINYLMETHYL)-2H-1,2,3-TRIAZOL-4-YL)METHYL)-, (2R)-
Systematic Name English
(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Systematic Name English
Code System Code Type Description
MANUFACTURER PRODUCT INFORMATION
(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
PUBCHEM
11635932
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
FDA UNII
WPL66843QN
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
CAS
393101-98-9
Created by admin on Sat Dec 16 11:03:31 GMT 2023 , Edited by admin on Sat Dec 16 11:03:31 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
INHIBITOR
SALT/SOLVATE -> PARENT
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ACTIVE MOIETY