Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H31F6N7O2.2ClH |
| Molecular Weight | 708.525 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=CC=CC=C56)C(F)(F)F
InChI
InChIKey=QBQHUKKLUVZUBC-MQWQBNKOSA-N
InChI=1S/C30H31F6N7O2.2ClH/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41;;/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40);2*1H/t23-;;/m1../s1
| Molecular Formula | C30H31F6N7O2 |
| Molecular Weight | 635.6033 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Bone marrow aplasia and liver damage caused by methimazole]. | 1998 Jun |
|
| [Methimazole-induced aplastic anemia]. | 1999 Sep |
|
| [Recovery from pancytopenia and liver dysfunction after administration of thiamazole for hyperthyroidism]. | 2000 Nov |
|
| Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. | 2001 |
|
| Drug-induced congenital defects: strategies to reduce the incidence. | 2001 |
|
| The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. | 2001 |
|
| Coexistence of Graves' disease and struma ovarii: case report and literature review. | 2001 Apr |
|
| Malignant hyperthermia in a patient with Graves' disease during subtotal thyroidectomy. | 2001 Apr |
|
| Morning granulocytopenia in a case of Graves' disease. | 2001 Apr |
|
| A case of pulmonary metastatic thyroid cancer complicated with Graves' disease. | 2001 Apr |
|
| [Simultaneous occurrence of Basedow's disease and autoimmune hemolytic anemia]. | 2001 Apr |
|
| Drug-dependent antibodies against the prodrug carbimazole do not react with the metabolite thiamazole. | 2001 Apr 1 |
|
| Use of percutaneous ethanol injection for treatment of bilateral hyperplastic thyroid nodules in cats. | 2001 Apr 15 |
|
| Clinical practice. Subclinical hyperthyroidism. | 2001 Aug 16 |
|
| Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats. | 2001 Dec |
|
| Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver. | 2001 Dec |
|
| The systolic function of the left ventricle of the heart in patients with hyperthyroidism during therapy. | 2001 Feb |
|
| Hyperthyroid dementia: clinicoradiological findings and response to treatment. | 2001 Feb 15 |
|
| Impact of neonatal hypothyroidism on Leydig cell number, plasma, and testicular interstitial fluid sex steroids concentration. | 2001 Feb-May |
|
| Basedow's disease and chronic ulcerative colitis: a case report and review of the Japanese literature. | 2001 Jan |
|
| Oxygen consumption in patients with hyperthyroidism before and after treatment with beta-blockade versus thyrostatic treatment: a prospective randomized study. | 2001 Jan |
|
| [Hyperthyroidism in early childhood and a very rare variant of glutaric aciduria: coincidence or causal relation?]. | 2001 Jan-Feb |
|
| Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment. | 2001 Jul |
|
| Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. | 2001 Jul 1 |
|
| Purification and catalytic properties of the chlorophenol 4-monooxygenase from Burkholderia cepacia strain AC1100. | 2001 Jun 11 |
|
| Influence of hypothyroid state on 45Ca(2+) influx and sensitivity of rat uterus to nifedipine and diltiazem. | 2001 Jun 15 |
|
| Neuronal expression of synaptotagmin-related gene 1 is regulated by thyroid hormone during cerebellar development. | 2001 Jun 15 |
|
| Stereological study on the submandibular gland in hypothyroid rats. | 2001 Mar |
|
| Effect of altered thyroid status on neurotrophin gene expression during postnatal development of the mouse cerebellum. | 2001 Mar |
|
| [A thyrotoxic myopathy accompanied with unusual muscle symptoms and MRI muscle findings]. | 2001 Mar |
|
| [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. | 2001 Mar 10 |
|
| Clinical, endocrinological and radiography features in a child with McCune-Albright syndrome and pituitary adenoma. | 2001 May |
|
| Bronchial asthma induced by an antithyroid drug. | 2001 May |
|
| Influence of nicotinamide on the radiosensitivity of normal and goitrous thyroid in the rat. | 2001 Nov |
|
| Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. | 2001 Nov |
|
| Thyroid hormones modify susceptibility to lidocaine-kindling in rats. | 2001 Oct 19 |
|
| Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. | 2001 Sep |
|
| Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids. | 2001 Sep |
|
| Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to Graves' disease. | 2001 Sep-Oct |
|
| Severe embryopathy and exposure to methimazole in early pregnancy. | 2002 Feb |
|
| Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats. | 2002 Feb |
|
| Depigmentation of brown Guinea pig skin by topical application of methimazole. | 2002 Jan |
|
| Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. | 2002 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:03:30 GMT 2023
by
admin
on
Sat Dec 16 11:03:30 GMT 2023
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| Record UNII |
H5KHP6OQ62
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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H5KHP6OQ62
Created by
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393183-40-9
Created by
admin on Sat Dec 16 11:03:30 GMT 2023 , Edited by admin on Sat Dec 16 11:03:30 GMT 2023
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16109663
Created by
admin on Sat Dec 16 11:03:30 GMT 2023 , Edited by admin on Sat Dec 16 11:03:30 GMT 2023
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PARENT -> SALT/SOLVATE |
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