SODIUM ANTHRANILATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6NO2.Na
Molecular Weight	159.1178
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].NC1=C(C=CC=C1)C([O-])=O

InChI

InChIKey=HCKKSLZDSNNSTL-UHFFFAOYSA-M

InChI=1S/C7H7NO2.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4H,8H2,(H,9,10);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: http://www.dailyhealthmagazine.com/vitamin-l1/https://www.drugs.com/inactive/aminobenzoate-sodium-185.html
Curator's Comment: description was created based on several sources, including: DOI: 10.2174/157017906777934926 | https://www.ncbi.nlm.nih.gov/pubmed/12844171

Sodium anthranilate is an excipient (pharmacologically inactive substance). Sodium anthranilate (Aminobenzoate sodium ,C7H6NNaO2), also known as sodium 2-aminobenzoate, is an organic amine. Aminobenzoate sodium exists as a yellow powder for use in pharmaceutical processing.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Anthranilate hydroxylase 4 Target ID: Anthranilate hydroxylase Sources: http://www.genome.jp/dbget-bin/www_bget?ec:1.14.16.3	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Obesity 203 Sources: https://www.drugs.com/imprints/ov-12-6970.html	Inactive ingredient	Approved 8429	Desoxyn Approved Use Desoxyn is used in the treatment of adhd; obesity and belongs to the drug classes anorexiants, CNS stimulants. Launch Date 1943
Intractable epilepsy 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25022821	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Schizophrenia 298 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27042691	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Research on tryptophan metabolites "via kynurenine" in epidermis of man and mouse.	1975	1244085
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.	2001	12092667
Update on sensitivity to nonsteroidal antiinflammatory drugs.	2001 Nov	12477289
Tranilast slows the progression of advanced diabetic nephropathy.	2002	12372957
Photocyclization of N,N-phthaloylanthranilic amides coupled to omega-amino acids with increasing chain lengths.	2002 Apr	12661962
Newer N-substituted anthranilic acid derivatives as potent anti-inflammatory agents.	2002 Aug	12161066
Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture.	2002 Aug 29	12225590
Location of abasic sites in oligodeoxynucleotides by tandem mass spectrometry and by a chemical cleavage initiated by an unusual reaction of the ODN with MALDI matrix.	2002 Dec	12484461
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.	2002 Dec 19	12477352
Ortho-aminobenzoic acid-labeled bradykinins in interaction with lipid vesicles: fluorescence study.	2002 Dec 5	12389213
Role of rhizobial biosynthetic pathways of amino acids, nucleotide bases and vitamins in symbiosis.	2002 Jul	12597544
Characterization of Trp(+) reversions in Escherichia coli strain WP2uvrA.	2002 Jul	12110627
The crystal structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum.	2002 Jul 17	12123839
Modification of carbon nanofibres for the immobilization of metal complexes: a case study with rhodium and anthranilic acid.	2002 Jul 2	12489215
[Structural variation of o-amino-benzoic acid induced by free electron laser].	2002 Jun	12938310
Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.	2002 Jun	12162538
Tranilast prevents activation of transforming growth factor-beta system, leukocyte accumulation, and neointimal growth in porcine coronary arteries after stenting.	2002 Jun 1	12067902
Biosynthesis of nodulisporic acid A: precursor studies.	2002 Jun 19	12059229
Toxicology and carcinogenesis studies of o-nitrotoluene sulfone (CAS no. 88-72-2) in F344/N rats and B6C3F(1) mice (feed studies).	2002 May	12087420
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.	2002 Nov	12419954
Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides.	2002 Nov 15	12201820
Yeast D-amino acid oxidase: structural basis of its catalytic properties.	2002 Nov 29	12445787
An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).	2002 Oct	12446040
Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase.	2002 Sep	12199711
Allergic contact dermatitis from etofenamate without cross-sensitization to other anthranilic acid derivatives.	2003	12771478
Lateral gene transfer and ancient paralogy of operons containing redundant copies of tryptophan-pathway genes in Xylella species and in heterocystous cyanobacteria.	2003	12620124
Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity.	2003 Aug 1	12737623
S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates.	2003 Aug 1	12733990
Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors.	2003 Feb 10	12565961
Glucose conjugation of anthranilate by the Arabidopsis UGT74F2 glucosyltransferase is required for tryptophan mutant blue fluorescence.	2003 Feb 21	12475971
High-performance liquid chromatography assay for 1-deoxy-D-xylulose 5-phosphate synthase activity using fluorescence detection.	2003 Feb 7	12597635
Complete nucleotide sequence of carbazole/dioxin-degrading plasmid pCAR1 in Pseudomonas resinovorans strain CA10 indicates its mosaicity and the presence of large catabolic transposon Tn4676.	2003 Feb 7	12547188
Total synthesis of (-)-fumiquinazolines A, B, C, E, H, and I. Approaches to the synthesis of fiscalin A.	2003 Jan 24	12530882
Kynurenines and the respiratory parameters on rat heart mitochondria.	2003 Jan 24	12505541
Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationships.	2003 Jan 29	12537428
Peptides to peptidomimetics: towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase.	2003 Jan 7	12929394
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein.	2003 Jul 1	12678920
Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate: characterization and functional expression of the quinaldine 4-oxidase qoxLMS genes.	2003 Jul 25	12730200
A quasi-tetrahedral Cu4 cluster and a helical-chain copper (II) complex with single syn-anti carboxylate bridges: crystal structure and magnetic properties.	2003 Jun 30	12817958
Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri.	2003 Mar	12634337
Separation of saccharides derivatized with 2-aminobenzoic acid by capillary electrophoresis and their structural consideration by nuclear magnetic resonance.	2003 Mar 1	12633611
Conjugate additions of o-iodoanilines and methyl anthranilates to acetylenic sulfones. A new route to quinolones including first syntheses of two alkaloids from the medicinal herb Ruta chalepensis.	2003 Mar 21	12636385
Complexity of coordinative bonding in thallium(I) anthranilates and salicylates.	2003 Mar 26	12643725
Anthranilic acid derivatives: a new class of non-peptide CCK1 receptor antagonists.	2003 Mar 6	12538004
Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors.	2003 May 1	12578561
A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs.	2003 May 19	12771932
Probing cathepsin K activity with a selective substrate spanning its active site.	2003 Oct 15	12837132
A concise total synthesis of (+/-)-alantrypinone by a novel hetero-Diels-Alder reaction.	2003 Sep 4	12943388
Waste-free and facile solid-state protection of diamines, anthranilic acid, diols, and polyols with phenylboronic acid.	2003 Sep 5	12953200
Production and analysis of organic acids in hairy-root cultures of Isatis indigotica Fort. (indigo woad).	2004 Feb	12962543

Patents

Sample Use Guides

In Vivo Use Guide

15,000 or 30,000 ppm for the rats, and either 25,000 or 50,000 ppm for the mice, 5 days per week for 78 weeks

Route of Administration: Oral

In Vitro Use Guide

The DNA damage effects of tryptophan metabolites were analyzed using plasmid relaxation assay performed with anthranilic acid at various concentrations between 50 uM and 400 uM in the presence of plasmid DNA pSP-72. Anthranilic acid did not show any plasmid relaxation activity.

Name

Type

Language

SODIUM ANTHRANILATE

Systematic Name

English

SODIUM 2-AMINOBENZOATE

Systematic Name

English

BENZOIC ACID, 2-AMINO-, MONOSODIUM SALT

Common Name

English

SODIUM O-AMINOBENZOATE

Common Name

English

ANTHRANILATOSODIUM

Common Name

English

ANTHRANILIC ACID, SODIUM SALT

Common Name

English

ANTHRANILIC ACID, MONOSODIUM SALT

Common Name

English

BENZOIC ACID, 2-AMINO-, SODIUM SALT (1:1)

Common Name

English

Code System Code Type Description

PUBCHEM

23674494