DUOPERONE FUMARATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H26F4N2OS.C4H4O4
Molecular Weight	630.65
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.FC1=CC=C(C=C1)C(=O)C2CCN(CCCN3C4=CC=CC=C4SC5=CC=C(C=C35)C(F)(F)F)CC2

InChI

InChIKey=YETRXLVOWPGIHR-WLHGVMLRSA-N

InChI=1S/C28H26F4N2OS.C4H4O4/c29-22-9-6-19(7-10-22)27(35)20-12-16-33(17-13-20)14-3-15-34-23-4-1-2-5-25(23)36-26-11-8-21(18-24(26)34)28(30,31)32;5-3(6)1-2-4(7)8/h1-2,4-11,18,20H,3,12-17H2;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/45570 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 474, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Duoperone is a neuroleptic agent. Duoperone blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. Conditioned avoidance responding in mice and cats was suppressed by duoperone in doses that did not impair escape behavior. Duoperone produced catalepsy in rats. The onset of this effect was delayed and the duration was prolonged when compared with that of chlorpromazine. It was a potent antiemetic agent in dogs, with a delayed onset and prolonged duration of action.

Approval Year

PubMed

Title	Date	PubMed

Name

Type

Language

DUOPERONE FUMARATE

Official Name

English

P-FLUOROPHENYL 1-(3-(2-(TRIFLUOROMETHYL)PHENOTHIAZIN-10-YL)PROPYL)-4-PIPERIDYL KETONE FUMARATE (1:1)

Common Name

English

METHANONE, (4-FLUOROPHENYL)(1-(3-(2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZIN-10-YL)PROPYL)-4-PIPERIDINYL)-, (E)-2-BUTENEDIOATE (1:1)

Systematic Name

English

AHR-6646

Code

English

AHR 6646

Code

English

DUOPERONE FUMARATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710