CLODAZON HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20ClN3O.ClH.H2O
Molecular Weight	384.3
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.Cl.CN(C)CCCN1C(=O)N(C2=CC(Cl)=CC=C12)C3=CC=CC=C3

InChI

InChIKey=KUSWMSGQGZMJGX-UHFFFAOYSA-N

InChI=1S/C18H20ClN3O.ClH.H2O/c1-20(2)11-6-12-21-16-10-9-14(19)13-17(16)22(18(21)23)15-7-4-3-5-8-15;;/h3-5,7-10,13H,6,11-12H2,1-2H3;1H;1H2

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5772001 | https://www.karger.com/Article/Abstract/467934

Clodazon (AW 142446) is an antidepressant drug investigated in Germany in the 1960s. In animal models, clodazon inhibits the catalepsy induced by tetrabenazine and it potentiates the effect of catecholamines, both effects being of the order experienced with imipramine. In clinical trials, about 2/3 of the patients showed a positive antidepressive effect with few side effects.

Approval Year

Name

Type

Language

CLODAZON HYDROCHLORIDE

Official Name

English

CLODAZON HYDROCHLORIDE [USAN]

Common Name

English

HUF-2446

Code

English

AW-14'2446

Code

English

CLODAZON HCL

Common Name

English

2H-BENZIMIDAZOL-2-ONE,5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-3-PHENYL-, MONOHYDROCHLORIDE, MONOHYDRATE

Systematic Name

English

AW-142446

Code

English

5-Chloro-1-[3-(dimethylamino)propyl]-3-phenyl-2-benzimidazolinone monohydrochloride monohydrate

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265