U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H20ClN3O.ClH.H2O
Molecular Weight 384.3
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLODAZON HYDROCHLORIDE

SMILES

O.Cl.CN(C)CCCN1C(=O)N(C2=CC(Cl)=CC=C12)C3=CC=CC=C3

InChI

InChIKey=KUSWMSGQGZMJGX-UHFFFAOYSA-N
InChI=1S/C18H20ClN3O.ClH.H2O/c1-20(2)11-6-12-21-16-10-9-14(19)13-17(16)22(18(21)23)15-7-4-3-5-8-15;;/h3-5,7-10,13H,6,11-12H2,1-2H3;1H;1H2

HIDE SMILES / InChI
Clodazon (AW 142446) is an antidepressant drug investigated in Germany in the 1960s. In animal models, clodazon inhibits the catalepsy induced by tetrabenazine and it potentiates the effect of catecholamines, both effects being of the order experienced with imipramine. In clinical trials, about 2/3 of the patients showed a positive antidepressive effect with few side effects.

Approval Year

Name Type Language
CLODAZON HYDROCHLORIDE
USAN  
USAN  
Official Name English
CLODAZON HYDROCHLORIDE [USAN]
Common Name English
HUF-2446
Code English
AW-14'2446
Code English
CLODAZON HCL
Common Name English
2H-BENZIMIDAZOL-2-ONE,5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-3-PHENYL-, MONOHYDROCHLORIDE, MONOHYDRATE
Systematic Name English
AW-142446
Code English
5-Chloro-1-[3-(dimethylamino)propyl]-3-phenyl-2-benzimidazolinone monohydrochloride monohydrate
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
Code System Code Type Description
FDA UNII
FSF9L5AH4G
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
PRIMARY
EPA CompTox
DTXSID40185789
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110801
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
PRIMARY
PUBCHEM
167451
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
PRIMARY
NCI_THESAURUS
C78012
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
PRIMARY
CAS
31959-88-3
Created by admin on Fri Dec 15 16:34:53 GMT 2023 , Edited by admin on Fri Dec 15 16:34:53 GMT 2023
PRIMARY