Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H10N2OS.ClH |
| Molecular Weight | 242.725 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC1=CC=C(NC2=NC=CS2)C(O)=C1
InChI
InChIKey=OAQDENGCTUPZEL-UHFFFAOYSA-N
InChI=1S/C10H10N2OS.ClH/c1-7-2-3-8(9(13)6-7)12-10-11-4-5-14-10;/h2-6,13H,1H3,(H,11,12);1H
Icoduline (previously known as CBS-113 A) is a dual inhibitor of 5-lipoxygenase and cyclo-oxygenase with anti-inflammatory properties. This drug was potentially useful in ophthalmology and as an alternative to glucocorticoids. In addition, icoduline was useful to treat skin disorders. The drug participated in the clinical trial for eye disorders in France; however, this study was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Electrochemical oxidation of CBS-113 A, a new anti-inflammatory drug: applicability to liquid chromatography-electrochemical detection. | 1995-08 |
|
| 2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 1st communication: in vitro studies. | 1989-10 |
|
| 2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 2nd communication: anti-inflammatory activity. | 1989-10 |
|
| Effects of lipoxygenase inhibitors on the arachidonic acid cascade in the rabbit cornea after injury. | 1988 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID30911913
Created by
admin on Mon Mar 31 18:13:25 GMT 2025 , Edited by admin on Mon Mar 31 18:13:25 GMT 2025
|
PRIMARY | |||
|
163834
Created by
admin on Mon Mar 31 18:13:25 GMT 2025 , Edited by admin on Mon Mar 31 18:13:25 GMT 2025
|
PRIMARY | |||
|
FRM2IBI8XA
Created by
admin on Mon Mar 31 18:13:25 GMT 2025 , Edited by admin on Mon Mar 31 18:13:25 GMT 2025
|
PRIMARY | |||
|
110952-54-0
Created by
admin on Mon Mar 31 18:13:25 GMT 2025 , Edited by admin on Mon Mar 31 18:13:25 GMT 2025
|
PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
