Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C11H12I3NO2 |
| Molecular Weight | 570.9319 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(CC1=C(I)C(N)=C(I)C=C1I)C(O)=O
InChI
InChIKey=OIRFJRBSRORBCM-UHFFFAOYSA-N
InChI=1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,2-3,15H2,1H3,(H,16,17)
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (1 patient) Sources: |
3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
Other AEs: Gastrointestinal disorders... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Diarrhea | 1 patient Disc. AE |
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
| Gastrointestinal disorders | 39 patients | 3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. | 2001 |
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| A test of the hypothesis that T3 is the "seasonality" thyroid hormone in American tree sparrows (Spizella arborea): intracerebroventricular infusion of iopanoic acid, an inhibitor of T3 synthesis and degradation. | 2001 Mar |
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| A surface-modified chylomicron remnant-like emulsion for percutaneous computed tomography lymphography: synthesis and preliminary imaging findings. | 2002 Apr |
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| Tissue-specific regulation of type III iodothyronine 5-deiodinase gene expression mediates the effects of prolactin and growth hormone in Xenopus metamorphosis. | 2002 Aug |
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| Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. | 2002 Sep |
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| Acute decrease in circulating T3 levels enhances, but does not normalise, the GH response to GHRP-6 plus GHRH in thyrotoxicosis. | 2003 Aug |
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| Use of oral cholecystography agents in the treatment of hyperthyroidism of subacute thyroiditis. | 2003 Mar |
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| Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. | 2003 Mar |
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| Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study. | 2003 May |
|
| Thyroid hormone-dependent seasonality in American tree sparrows (Spizella arborea): effects of GC-1, a thyroid receptor beta-selective agonist, and of iopanoic acid, a deiodinase inhibitor. | 2004 Aug |
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| Treatment of hyperthyroidism associated with thyrotropin-secreting pituitary adenomas with iopanoic acid. | 2004 Feb |
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| Iopanoic acid in the management of neonatal Graves' disease. | 2004 Feb |
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| Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis. | 2004 Feb 1 |
|
| [Levothyroxine poisoning: clinical manifestations and therapeutic management]. | 2004 Jan |
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| Oral contrast-enhanced CT cholangiography--an initial experience. | 2004 Jan |
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| Rapid preparation of severe uncontrolled thyrotoxicosis due to Graves' disease with Iopanoic acid--a case report. | 2004 Jan |
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| Rapid preoperative preparation for severe hyperthyroid Graves' disease. | 2004 May |
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| Effects of tetraiodothyronine and triiodothyronine on hamster cheek pouch microcirculation. | 2005 Apr |
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| Effect of iopanoic acid on radioiodine therapy of hyperthyroidism: long-term outcome of a randomized controlled trial. | 2005 Dec |
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| Thin-section multiplanar reformats from multidetector-row CT data: utility for assessment of regional tumor extent in non-small cell lung cancer. | 2005 Oct |
|
| Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds. | 2006 Jan |
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| Amiodarone-induced thyrotoxicosis. A review. | 2008 Sep |
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| Effects and safety of iopanoic acid in cats administered levothyroxine. | 2009 Feb |
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| Analysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife. | 2010 Jul 15 |
|
| Colloid formation by drugs in simulated intestinal fluid. | 2010 May 27 |
|
| Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. | 2013 Jun |
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| Classification Tree | Code System | Code | ||
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WHO-VATC |
QV08AC06
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WHO-ATC |
V08AC06
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NCI_THESAURUS |
C28500
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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3
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41706
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5967
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3735
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3345
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FE9794P71J
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100000083105
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IOPANOIC ACID
Created by
admin on Sat Dec 16 16:42:39 UTC 2023 , Edited by admin on Sat Dec 16 16:42:39 UTC 2023
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PRIMARY | Description: A light yellowish white powder; odour, faint, characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS, and acetone R; dissolves in solutions of alkali hydroxides. Category: Radiocontrast medium. Storage: Iopanoic acid should be kept in a tightly closed container, protected from light. Iopanoic acid is gradually affected by light. Requirements: Iopanoic acid contains not less than 97.0% and not more than the equivalent of 101.0% of C11H12I3NO2, calculated with reference to the dried substance. | ||
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SUB08240MIG
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637485
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202-539-9
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DB08946
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m6371
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17879-93-5
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SUPERSEDED | |||
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Iopanoic acid
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96-83-3
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DTXSID6023159
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CHEMBL867
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C65942
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1465
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D007480
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
