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Details

Stereochemistry ACHIRAL
Molecular Formula C9H12N6
Molecular Weight 204.2318
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIETHYLENEMELAMINE

SMILES

C1CN1C2=NC(=NC(=N2)N3CC3)N4CC4

InChI

InChIKey=IUCJMVBFZDHPDX-UHFFFAOYSA-N
InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2

HIDE SMILES / InChI
TRIETHYLENEMELAMINE, an aziridine derivative, is an alkylating agent with antineoplastic properties. Formerly it was used in the palliative treatment of the lymphomas and leukemias. Now it is used as a research tool to produce chromosome aberrations and cancers.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Tretamine

Approved Use

Antineoplastic.

Launch Date

-5.04921588E11
Doses

Doses

DosePopulationAdverse events​
5 mg 1 times / day multiple, oral (starting)
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
unhealthy, 41 - 70 years
n = 6
Health Status: unhealthy
Condition: POLYCYTHEMIA VERA
Age Group: 41 - 70 years
Sex: M+F
Population Size: 6
Sources:
Disc. AE: Nausea, Vomiting...
AEs leading to
discontinuation/dose reduction:
Nausea (severe, 1 patient)
Vomiting (severe, 1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Nausea severe, 1 patient
Disc. AE
5 mg 1 times / day multiple, oral (starting)
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
unhealthy, 41 - 70 years
n = 6
Health Status: unhealthy
Condition: POLYCYTHEMIA VERA
Age Group: 41 - 70 years
Sex: M+F
Population Size: 6
Sources:
Vomiting severe, 1 patient
Disc. AE
5 mg 1 times / day multiple, oral (starting)
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
unhealthy, 41 - 70 years
n = 6
Health Status: unhealthy
Condition: POLYCYTHEMIA VERA
Age Group: 41 - 70 years
Sex: M+F
Population Size: 6
Sources:
PubMed

PubMed

TitleDatePubMed
Visual fields in retinoblastoma survivors.
2004 Sep
Capture of carbon dioxide by amine-impregnated as-synthesized MCM-41.
2010
Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.
2010 Jun 28
A new alkaloid isolated from Abies webbiana leaf.
2010 May
Patents

Patents

Name Type Language
TRIETHYLENEMELAMINE
HSDB   MI  
Common Name English
2,4,6-TRIS(1-AZIRIDINYL)-S-TRIAZINE
Common Name English
2,4,6-TRIS(1-AZIRIDINYL)-S-TRIAZINE [IARC]
Common Name English
Tretamine [WHO-DD]
Common Name English
TRIETHYLENE MELAMINE
Common Name English
2,4,6-TRIS(1-AZIRIDINYL)-1,3,5-TRIAZINE
Systematic Name English
TRIETHYLENEMELAMINE [MI]
Common Name English
TRETAMINE [MART.]
Common Name English
1,3,5-TRIAZINE, 2,4,6-TRIS(1-AZIRIDINYL)-.
Common Name English
2,4,6-TRI(AZIRIDIN-1-YL)-1,3,5-TRIAZINE
Systematic Name English
TRETAMINE
INN   MART.   WHO-DD  
INN  
Official Name English
TRIETHYLENEMELAMINE [HSDB]
Common Name English
tretamine [INN]
Common Name English
NSC-9706
Code English
Classification Tree Code System Code
NCI_THESAURUS C292
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C29858
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
DRUG BANK
DB14031
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
WIKIPEDIA
TRIETHYLENEMELAMINE
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
PUBCHEM
5799
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
CHEBI
27919
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
FDA UNII
F7IY6HZG9D
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
INN
329
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
ChEMBL
CHEMBL502384
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-083-5
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
MERCK INDEX
m11106
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY Merck Index
NSC
9706
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
CAS
51-18-3
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
EPA CompTox
DTXSID3026225
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
EVMPD
SUB11243MIG
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
DRUG CENTRAL
2739
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
MESH
D014265
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
HSDB
4000
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
SMS_ID
100000077506
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY
ALANWOOD
tretamine
Created by admin on Fri Dec 15 16:27:45 UTC 2023 , Edited by admin on Fri Dec 15 16:27:45 UTC 2023
PRIMARY