Cimdelirsen

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Name

Type

Language

Cimdelirsen

Official Name

English

DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-sp-T-sp-T-sp-T-sp-G-sp-G-sp-G-sp-T-sp-G-sp-A-sp-A-sp-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)

Common Name

English

ISIS-766720

Code

English

CIMDELIRSEN [USAN]

Common Name

English

IONIS-GHR-LRX FREE ACID

Code

English

cimdelirsen [INN]

Common Name

English

all-P-ambo-5′-O-{[(6-{5-[(tris{3-[6-(2-acetamido-2-deoxy-β-Dgalactopyranosyloxy)hexylamino]-3-oxopropoxymethyl})methyl]amino-5-oxopentanamido}hexyl)]phospho}-2′-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3′-O→5′-O)-2′-O-(2-methoxyethyl)-5-

Common Name

English

IONIS-GHR-LRX FREE ACID(ANTISENSE INHIBITOR OF THE GROWTH HORMONE RECEPTOR)

Common Name

English

Code System Code Type Description

INN

11675

Created by admin on Sat Dec 16 15:07:46 GMT 2023 , Edited by admin on Sat Dec 16 15:07:46 GMT 2023

PRIMARY

USAN

GH-83

Created by admin on Sat Dec 16 15:07:46 GMT 2023 , Edited by admin on Sat Dec 16 15:07:46 GMT 2023

PRIMARY

FDA UNII

F593G1C1YO

Created by admin on Sat Dec 16 15:07:46 GMT 2023 , Edited by admin on Sat Dec 16 15:07:46 GMT 2023

PRIMARY

NCI_THESAURUS

C162807

Created by admin on Sat Dec 16 15:07:46 GMT 2023 , Edited by admin on Sat Dec 16 15:07:46 GMT 2023

PRIMARY

CAS

2131025-82-4

Created by admin on Sat Dec 16 15:07:46 GMT 2023 , Edited by admin on Sat Dec 16 15:07:46 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_1-1_2;1_5-1_15;1_18-1_19	15 / 19
Phosphate	1_3-1_4;1_16-1_17	4 / 19

ACTIVE MOIETY


					F593G1C1YO

METABOLITE ACTIVE (PRODRUG)


					ZEQ8SWG4AT

CIMDELIRSEN SODIUM ACTIVE METABOLITE

SALT/SOLVATE (PARENT)


					1FN0H304ZQ

Cimdelirsen Sodium