Cimdelirsen Sodium

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 15:03:36 GMT 2023` Edited by `admin` on `Sat Dec 16 15:03:36 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	1FN0H304ZQ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Cimdelirsen Sodium

Official Name

English

IONIS-GHR-LRX

Code

English

CIMDERLIRSEN SODIUM

Common Name

English

IONIS-GHR-LRX (ANTISENSE INHIBITOR OF THE GROWTH HORMONE RECEPTOR)

Common Name

English

ISIS-766720 SODIUM

Code

English

all-P-ambo-5'-O-(28-[(2-acetamido-2-deoxy-β-d-galactopyranosyl)oxy]-16,16-bis{[3-({6-[(2-acetamido-2-deoxy-β-d-galactopyranosyl)oxy]hexyl}amino)3-oxopropoxy]methyl}-1-hydroxy-1,10,14,21-tetraoxo-2,18-dioxa-9,15,22-triaza-1λ5-phosphaoctacosan-1-yl)-2'-

Common Name

English

CIMDELIRSEN SODIUM [USAN]

Common Name

English

DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-sp-T-sp-Tsp-T-sp-G-sp-G-sp-G-sp-T-sp-G-sp-A-sp-A-sp-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]

Common Name

English

Code System Code Type Description

CAS

2131025-83-5

Created by admin on Sat Dec 16 15:03:36 GMT 2023 , Edited by admin on Sat Dec 16 15:03:36 GMT 2023

PRIMARY

NCI_THESAURUS

C180504

Created by admin on Sat Dec 16 15:03:36 GMT 2023 , Edited by admin on Sat Dec 16 15:03:36 GMT 2023

PRIMARY

USAN

GH-84

Created by admin on Sat Dec 16 15:03:36 GMT 2023 , Edited by admin on Sat Dec 16 15:03:36 GMT 2023

PRIMARY

FDA UNII

1FN0H304ZQ

Created by admin on Sat Dec 16 15:03:36 GMT 2023 , Edited by admin on Sat Dec 16 15:03:36 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
	1_3-1_4;1_16-1_17	4 / 19
Sodium Phosporothioate	1_1-1_2;1_5-1_15;1_18-1_19	15 / 19

Related Record Type Details


					F593G1C1YO

Cimdelirsen

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					F593G1C1YO

Cimdelirsen

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	708789d3 (not in database)
NUCLEOSIDE BASE SUBSTITUTION	[1_2] [1_4] [1_5] [1_19]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H