U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 14:24:31 GMT 2023
Edited
by admin
on Sat Dec 16 14:24:31 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
ZEQ8SWG4AT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIMDELIRSEN SODIUM ACTIVE METABOLITE
Common Name English
ISIS-766720 ACTIVE METABOLITE
Code English
IONIS-GHR-LRX ACTIVE METABOLITE
Code English
IONIS-GHR-LRX ACTIVE METABOLITE (ANTISENSE INHIBITOR OF THE GROWTH HORMONE RECEPTOR)
Common Name English
Code System Code Type Description
FDA UNII
ZEQ8SWG4AT
Created by admin on Sat Dec 16 14:24:31 GMT 2023 , Edited by admin on Sat Dec 16 14:24:31 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Deoxyribose (DNA) 1_6-1_15 10 / 20
Linkage Site Range Site Count
Phosporothioate 1_1-1_2;1_5-1_15;1_18-1_19 15 / 19
Phosphate 1_3-1_4;1_16-1_17 4 / 19
Related Record Type Details
TARGET->INHIBITOR OF EXPRESSION
Related Record Type Details
PRODRUG -> METABOLITE ACTIVE

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION [1_1] [1_2] [1_4] [1_5] [1_19] SITE_SPECIFIC 5-METHYLCYTOSINE 6R795CQT4H