CIMDELIRSEN SODIUM ACTIVE METABOLITE

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 23:32:57 GMT 2025` Edited by `admin` on `Tue Apr 01 23:32:57 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	ZEQ8SWG4AT
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Common Name

English

IONIS-GHR-LRX ACTIVE METABOLITE

Preferred Name

English

ISIS-766720 ACTIVE METABOLITE

Code

English

IONIS-GHR-LRX ACTIVE METABOLITE (ANTISENSE INHIBITOR OF THE GROWTH HORMONE RECEPTOR)

Common Name

English

Code System Code Type Description

FDA UNII

ZEQ8SWG4AT

Created by admin on Tue Apr 01 23:32:57 GMT 2025 , Edited by admin on Tue Apr 01 23:32:57 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_1-1_2;1_5-1_15;1_18-1_19	15 / 19
Phosphate	1_3-1_4;1_16-1_17	4 / 19

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_1] [1_2] [1_4] [1_5] [1_19]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H