AMIQUINSIN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12N2O2.ClH.H2O
Molecular Weight	258.701
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.Cl.COC1=C(OC)C=C2C(N)=CC=NC2=C1

InChI

InChIKey=QJWVFNYHDZZWDS-UHFFFAOYSA-N

InChI=1S/C11H12N2O2.ClH.H2O/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2;;/h3-6H,1-2H3,(H2,12,13);1H;1H2

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5463588

Amiquinsin hydrochloride, 4-amino-6,7-dimethoxquinoline hydrochloride hydrate, is a drug, which exhibits hypotensive activity. Amiquinsin has a more prolonged hypotensive effect than the hydroxyquinoline.

Originator

Approval Year

PubMed

Title	Date	PubMed
Isolation, identification, and synthesis of 4-amino-6,7-dimethoxy-3-quinolinol, the major metabolite of amiquinsin hydrochloride in rats and humans.	1980-07	7391952
Studies on the absorption, distribution, and elimination of amiquinsin hydrochloride, a hypotensive drug.	1970	5463588

Patents

Sample Use Guides

In Vivo Use Guide

Amiquinsin hydrochloride was administered orally (10-40 mg/kg) to dogs as crystalline material in gelatin capsules. The drug was also administered parenterally (intravenously or intramuscularly, 2.5-10 mg/kg) to dogs as a solution in 5% dextrose, pH 4.4 to 4.8. Drug solutions were infused intravenously at a rate of 1.91 ml/min and at doses ranging from 1.25 to 10.00 mg/kg per hr using a Harvard pump.

Route of Administration: Other

Name

Type

Language

U-935

Preferred Name

English

AMIQUINSIN HYDROCHLORIDE

Official Name

English

4-QUINOLINAMINE, 6,7-DIMETHOXY-, MONOHYDROCHLORIDE, MONOHYDRATE

Common Name

English

AMIQUINSIN HYDROCHLORIDE [USAN]

Common Name

English

AMIQUINSIN HCL

Common Name

English

4-Amino-6,7-dimethoxyquinoline hydrochloride monohydrate

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270