Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H26N4O6.4ClH |
| Molecular Weight | 468.202 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.Cl.Cl.[H][C@]2(O[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O)O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N
InChI
InChIKey=YHGAXELMYJIVJN-OXGCEHIISA-N
InChI=1S/C12H26N4O6.4ClH/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20;;;;/h3-12,17-20H,1-2,13-16H2;4*1H/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-;;;;/m1..../s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Screening for new compounds with antiherpes activity. | 1984 Oct |
|
| Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. | 1993 Sep 24 |
|
| Study of aminoglycoside-nucleic acid interactions by an HPLC method. | 2001 Apr 23 |
|
| Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. | 2001 Feb 26 |
|
| An efficient synthesis of mimetics of neamine for RNA recognition. | 2001 May 31 |
|
| Design of novel antibiotics that bind to the ribosomal acyltransfer site. | 2002 Apr 3 |
|
| Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. | 2002 Jun |
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| Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide. | 2003 Feb 28 |
|
| Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step. | 2003 Nov |
|
| Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues. | 2004 Feb 19 |
|
| Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria. | 2004 Mar 9 |
|
| Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics. | 2004 May |
|
| Structure-activity relationships of aminoglycoside-arginine conjugates that bind HIV-1 RNAs as determined by fluorescence and NMR spectroscopy. | 2004 Nov 19 |
|
| Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: identification of high-affinity displacers and DNA-binding ligands. | 2004 Oct 6 |
|
| A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication. | 2004 Sep 23 |
|
| Disaccharide mimetics of the aminoglycoside antibiotic neamine. | 2004 Sep 6 |
|
| Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. | 2005 Apr 15 |
|
| Neamine inhibits xenografic human tumor growth and angiogenesis in athymic mice. | 2005 Dec 15 |
|
| The RNA-bound conformation of neamine as determined by transferred NOE experiments. | 2005 Jul |
|
| Neamine dimers targeting the HIV-1 TAR RNA. | 2005 Nov 1 |
|
| Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat. | 2006 Apr 15 |
|
| A molecular dynamics simulation study of an aminoglycoside/A-site RNA complex: conformational and hydration patterns. | 2006 Aug |
|
| Synthesis and antibacterial activity of novel neamine derivatives. | 2006 Dec 15 |
|
| Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. | 2006 Feb |
|
| Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides. | 2006 Jul |
|
| Cationic polyamines inhibit anthrax lethal factor protease. | 2006 Jun 8 |
|
| Determination of tobramycin and impurities using high-performance anion exchange chromatography with integrated pulsed amperometric detection. | 2006 Mar 3 |
|
| Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. | 2006 Oct 1 |
|
| Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. | 2007 |
|
| Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates. | 2007 Dec |
|
| Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate. | 2007 Fall |
|
| Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. | 2007 Feb 12 |
|
| Determination of neomycin sulfate and impurities using high-performance anion-exchange chromatography with integrated pulsed amperometric detection. | 2007 Jan 4 |
|
| Unique O-ribosylation in the biosynthesis of butirosin. | 2007 Jul 1 |
|
| Design and synthesis of a structurally constrained aminoglycoside. | 2007 Jul 6 |
|
| Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. | 2007 Jun 1 |
|
| Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching. | 2007 Jun 1 |
|
| Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discovery. | 2007 Mar 21 |
|
| Synthesis of a neamine dimer targeting the dimerization initiation site of HIV-1 RNA. | 2007 Oct 25 |
|
| Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. | 2008 Aug 20 |
|
| Identification of tobramycin impurities for quality control process monitoring using high-performance anion-exchange chromatography with integrated pulsed amperometric detection. | 2008 Aug 5 |
|
| Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. | 2008 Dec 2 |
|
| Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption. | 2008 Feb |
|
| Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. | 2008 Jan |
|
| Copper(II) complexes of lipophilic aminoglycoside derivatives for the amino acid enantiomeric separation by ligand-exchange liquid chromatography. | 2008 Mar 28 |
|
| Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. | 2008 Oct 15 |
|
| Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics. | 2009 Apr 28 |
|
| Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription. | 2009 Mar 15 |
|
| Neamine inhibits cell proliferation, migration, and invasion in H7402 human hepatoma cells. | 2010 Dec |
|
| Aminoglycoside binding to Oxytricha nova telomeric DNA. | 2010 Nov 16 |
Patents
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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EIU453IDVS
Created by
admin on Fri Dec 15 15:03:17 GMT 2023 , Edited by admin on Fri Dec 15 15:03:17 GMT 2023
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PRIMARY | |||
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11784617
Created by
admin on Fri Dec 15 15:03:17 GMT 2023 , Edited by admin on Fri Dec 15 15:03:17 GMT 2023
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PRIMARY | |||
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15446-43-2
Created by
admin on Fri Dec 15 15:03:17 GMT 2023 , Edited by admin on Fri Dec 15 15:03:17 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
