Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H26N4O6.4ClH |
| Molecular Weight | 468.202 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.Cl.Cl.[H][C@]2(O[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O)O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N
InChI
InChIKey=YHGAXELMYJIVJN-OXGCEHIISA-N
InChI=1S/C12H26N4O6.4ClH/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20;;;;/h3-12,17-20H,1-2,13-16H2;4*1H/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-;;;;/m1..../s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C12H26N4O6 |
| Molecular Weight | 322.358 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Screening for new compounds with antiherpes activity. | 1984 Oct |
|
| Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. | 1993 Sep 24 |
|
| Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element. | 2000 Jan-Feb |
|
| Study of aminoglycoside-nucleic acid interactions by an HPLC method. | 2001 Apr 23 |
|
| Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. | 2001 Feb 26 |
|
| An efficient synthesis of mimetics of neamine for RNA recognition. | 2001 May 31 |
|
| Design of novel antibiotics that bind to the ribosomal acyltransfer site. | 2002 Apr 3 |
|
| Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide. | 2003 Feb 28 |
|
| Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues. | 2004 Feb 19 |
|
| Neamine inhibits xenografic human tumor growth and angiogenesis in athymic mice. | 2005 Dec 15 |
|
| Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat. | 2006 Apr 15 |
|
| A molecular dynamics simulation study of an aminoglycoside/A-site RNA complex: conformational and hydration patterns. | 2006 Aug |
|
| Cationic polyamines inhibit anthrax lethal factor protease. | 2006 Jun 8 |
|
| Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. | 2006 Oct 1 |
|
| Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate. | 2007 Fall |
|
| Synthesis of a neamine dimer targeting the dimerization initiation site of HIV-1 RNA. | 2007 Oct 25 |
|
| Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. | 2008 Jan |
|
| Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. | 2008 Oct 15 |
|
| Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine. | 2009 Jan |
|
| Neamine inhibits cell proliferation, migration, and invasion in H7402 human hepatoma cells. | 2010 Dec |
|
| Aminoglycoside binding to Oxytricha nova telomeric DNA. | 2010 Nov 16 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:03:17 GMT 2023
by
admin
on
Fri Dec 15 15:03:17 GMT 2023
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| Record UNII |
EIU453IDVS
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| Record Status |
Validated (UNII)
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| Record Version |
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EIU453IDVS
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11784617
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15446-43-2
Created by
admin on Fri Dec 15 15:03:17 GMT 2023 , Edited by admin on Fri Dec 15 15:03:17 GMT 2023
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |