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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H30N4O3
Molecular Weight 398.4986
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ENERISANT

SMILES

C[C@@H]1CCCN1CCCOC2=CC=C(C=C2)N3C=C(C=N3)C(=O)N4CCOCC4

InChI

InChIKey=IABXVJILZYNSTM-GOSISDBHSA-N
InChI=1S/C22H30N4O3/c1-18-4-2-9-24(18)10-3-13-29-21-7-5-20(6-8-21)26-17-19(16-23-26)22(27)25-11-14-28-15-12-25/h5-8,16-18H,2-4,9-15H2,1H3/t18-/m1/s1

HIDE SMILES / InChI

Description

Enerisant is a histamine H3 receptor antagonist. In H3 receptor binding assay using (R)​-​α-​methyl[3H]​histamine, enerisant showed IC50 of 4.9 nM. Enerisant may be useful for the treatment of Alzheimer's disease, schizophrenia, etc.

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Histamine H3 receptor
44
Antagonist
2,778
 4.9 nM [IC50]
ACTIVE MOIETY
Structure of ENERISANT
SALT/SOLVATE (PARENT)
Structure of ENERISANT HYDROCHLORIDE
NIH
NCATS
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