SODIUM PHOSPHATE, DIBASIC, DODECAHYDRATE

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Na.HO4P.12H2O
Molecular Weight	358.1422
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SODIUM PHOSPHATE, DIBASIC, DODECAHYDRATE

Structure Search

SMILES

O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O

InChI

InChIKey=DGLRDKLJZLEJCY-UHFFFAOYSA-L

InChI=1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21250045https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/18582scs031_procalAmine_lbl.pdf | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58f0330d-0c16-4505-913d-26cccf42ae99

Phosphoric acid, also known as orthophosphoric acid, is used in dentistry and orthodontics to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed. In addition, this acid is a part of product ProcalAmine, which is indicated for peripheral administration in adults to preserve body protein and improve nitrogen balance in well-nourished, mildly catabolic patients who require short-term parenteral nutrition. In combination with dextrose (glucose) and levulose (fructose), phosphoric acid relieves nausea due to upset stomach from intestinal flu, stomach flu, and food or drink indiscretions. In addition, homeopathic product, Brain power contains also phosphoric acid and this product is used to temporarily relieve symptoms of general physical weakness and listlessness, including: fatigue; sore muscles & joints; dry skin; absence of sexual desire; occasional sleeplessness.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Lose body protein 27 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/18582scs031_procalAmine_lbl.pdf	Palliative	Approved 8429	PROCALAMINE Approved Use ProcalAmine is indicated for peripheral administration in adults to preserve body protein and improve nitrogen balance in well-nourished, mildly catabolic patients who require short-term parenteral nutrition. Launch Date 1982
Nausea 63 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b8dc39e1-e03e-4db8-a76d-dba72aad9a49	Palliative	Not Provided 504	Unknown Approved Use Unknown
Fatigue 46 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58f0330d-0c16-4505-913d-26cccf42ae99	Palliative	Not Provided 504	Unknown Approved Use Unknown
Occasional sleeplessness 37 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58f0330d-0c16-4505-913d-26cccf42ae99	Palliative	Not Provided 504	Unknown Approved Use Unknown
Sore muscles & joints 27 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58f0330d-0c16-4505-913d-26cccf42ae99	Palliative	Not Provided 504	Unknown Approved Use Unknown
Hypophosphatemia 30 Sources: http://www.iasj.net/iasj?func=fulltext&aId=44752	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Hyperphosphatemia 30 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21250045	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Hypophosphatemia 30 Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=3d066575-f361-4fcc-b1f3-3ae2be447719&type=display	Primary	Approved 8429	SODIUM PHOSPHATES INJECTION Approved Use Sodium Phosphates Injection, USP, 3mM P/mL, is indicated as a source of phosphorus, for addition to large volume intravenous fluids, to prevent or correct hypophosphatemia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. The concomitant amount of sodium (4 mEq/mL) must be calculated into total electrolyte content of such prepared solutions.

PubMed

Title	Date	PubMed
Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation.	1967 Feb	5336272
Determination of inorganic phosphate in serum and saliva using a synthetic receptor.	2003 Jun 12	12790520
Amperometric biosensor for determining human salivary phosphate.	2005 Aug 15	15993373
Phosphorus amendment reduces hepatic and renal oxidative stress in mallards ingesting lead-contaminated sediments.	2006 Jun	16840252

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

SODIUM PHOSPHATE, DIBASIC DODECAHYDRATE

Preferred Name

English

SODIUM PHOSPHATE, DIBASIC, DODECAHYDRATE

Common Name

English

PHOSPHORIC ACID DISODIUM DODECAHYDRATE

Systematic Name

English

DISODIUM HYDROGEN PHOSPHATE, DODECAHYDRATE

Systematic Name

English

DISODIUM PHOSPHATE DODECAHYDRATE [EP MONOGRAPH]

Common Name

English

MONOSODIUM PHOSPHATE DODECAHYDRATE

Systematic Name

English

DISODIUM PHOSPHATE (NA2HPO4.12H2O)

Common Name

English

DISODIUM PHOSPHATE (NA2HPO4) DODECAHYDRATE

Common Name

English

DISODIUM PHOSPHATE DODECAHYDRATE

Systematic Name

English

DISODIUM HYDROGEN ORTHOPHOSPHATE DODECAHYDRATE

Systematic Name

English

SODIUM PHOSPHATE, DIBASIC DODECAHYDRATE [MI]

Common Name

English

DISODIUM ORTHOPHOSPHATE, DODECAHYDRATE

Systematic Name

English

DIBASIC SODIUM PHOSPHATE HYDRATE [JAN]

Common Name

English

SODIUM PHOSPHATE (NA2HPO4) DODECAHYDRATE

Common Name

English

DISODIUM PHOSPHATE DODECAHYDRATE (NA2HPO4.12H2O)

Common Name

English

Sodium phosphate dibasic dodecahydrate [WHO-DD]

Common Name

English

DIBASIC SODIUM PHOSPHATE HYDRATE

Common Name

English

MONOHYDROGEN DISODIUM PHOSPHATE DODECAHYDRATE

Common Name

English

SODIUM PHOSPHATE, DIBASIC, DODECAHYDRATE [II]

Common Name

English

PHOSPHORIC ACID, DISODIUM SALT, DODECAHYDRATE

Common Name

English

DISODIUM PHOSPHATE DODECAHYDRATE [EP IMPURITY]

Common Name

English

DIBASIC SODIUM PHOSPHATE, DODECAHYDRATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29730