Details
Stereochemistry | RACEMIC |
Molecular Formula | C16H33NO2 |
Molecular Weight | 271.4387 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(CCC)CCCC1COCCN1CCO
InChI
InChIKey=QSFOWAYMMZCQNF-UHFFFAOYSA-N
InChI=1S/C16H33NO2/c1-3-6-15(7-4-2)8-5-9-16-14-19-13-11-17(16)10-12-18/h15-16,18H,3-14H2,1-2H3
Delmopinol, a surface-active cationic agent. It was approved by FDA under the name Decapinol for the treatment of gingivitis and prevention of periodontitis. The drug interacts with the early acquired pellicle, the thin layer of saliva polymers and proteins covering teeth and gums, and forms a barrier over teeth and gums. This barrier prevents the microbial adhesion and colonisation on the tooth and gum surface. Delmopinol itself has no bactericidal activity.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: Dental pellicle |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | DECAPINOL Approved UseDECAPINOL is a novel, first in class, medical device to help treat gingivitis and prevent periodontitis by preventing the plaque formation on the teeth’s and gum’s surface. Launch Date2004 |
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Preventing | DECAPINOL Approved UseDECAPINOL is a novel, first in class, medical device to help treat gingivitis and prevent periodontitis by preventing the plaque formation on the teeth’s and gum’s surface. Launch Date2004 |
Sample Use Guides
Mouthwash formulation: Rinse 10ml of delmopinol (Decapinol mouthwash) for 30 sec and expectorate, use twice a day, avoid eating and drinking for about 30 minutes after the use of the mouthwash. Toothpaste formulation: Brush your teeth with delmopinol (decapinol toothpaste) as instructed by your dental professional.
Route of Administration:
Dental
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28169264
Bacteria isolated from samples of human dental plaque were treated with delmopinol mouthwash. Different dilutions of the delmopinol (100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78%, 0.39%, 0.19%) were tested to determine the MIC of bacterial growth. MIC values were 0.78% for Streptococcus mutants, 1.56% for Lactobacillus and 6.25 and 3.12 for aerobic and anaerobic bacterias, respectively.
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C83486
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)