Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C23H44O5 |
| Molecular Weight | 400.5925 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCC
InChI
InChIKey=GNSDEDOVXZDMKM-UHFFFAOYSA-N
InChI=1S/C23H44O5/c1-3-5-7-9-11-13-15-17-22(25)27-20-21(19-24)28-23(26)18-16-14-12-10-8-6-4-2/h21,24H,3-20H2,1-2H3
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets. | 1985 Feb 10 |
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| 1,2-Didecanoylglycerol and phorbol 12,13-dibutyrate enhance anterior pituitary hormone secretion in vitro. | 1985 Oct |
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| sn-1,2-Diacylglycerols mimic the effects of 12-O-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. | 1986 Nov |
|
| Diacylglycerol inhibits potassium-induced calcium influx and insulin release by a protein kinase-C-independent mechanism in HIT T-15 islet cells. | 1992 Oct |
|
| Chitosan does not inhibit enzymatic action of human pancreatic lipase in Langmuir monolayers of 1,2-didecanoyl-glycerol (DDG). | 2014 Nov 1 |
Sample Use Guides
1,2-Didecanoylglycerol (glyceryl 1,2-dicaprate) was evaluated as a complete skin tumor promoter in CD-1 mice : mice were initiated with 200 nmol 7,12-dimethylbenz[a]anthracene. One week later the mice received twice daily topical applications of 1 nmol TPA, 2 mumol sn-1,2-didecanoylglycerol or 5 mumol sn-1,2-didecanoylglycerol, 5 days/week.
Route of Administration:
Transdermal
ACTH and beta-endorphin (beta-End) secretion were enhanced by 1,2-didecanoylglycerol (glyceryl 1,2-dicaprate/DiC10) in a concentration-dependent manner, with a minimal effective concentration of 5 microM. The effect of DiC10 was time dependent, with maximal responses occurring at 15-30. Release of GH was also enhanced significantly by DiC10 with minimal effective concentrations of 1 microM. In additional experiments, the effects of DiC10 on secretion of LH, FSH, PRL, and TSH were evaluated. The results indicate that 5-25 microM DiC10 produced a concentration-dependent release of each of those hormones.
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D5K11SW7QP
Created by
admin on Fri Dec 15 16:44:05 GMT 2023 , Edited by admin on Fri Dec 15 16:44:05 GMT 2023
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1321
Created by
admin on Fri Dec 15 16:44:05 GMT 2023 , Edited by admin on Fri Dec 15 16:44:05 GMT 2023
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SUBSTANCE RECORD
