Details
Stereochemistry | RACEMIC |
Molecular Formula | C23H44O5 |
Molecular Weight | 400.5925 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCC
InChI
InChIKey=GNSDEDOVXZDMKM-UHFFFAOYSA-N
InChI=1S/C23H44O5/c1-3-5-7-9-11-13-15-17-22(25)27-20-21(19-24)28-23(26)18-16-14-12-10-8-6-4-2/h21,24H,3-20H2,1-2H3
Molecular Formula | C23H44O5 |
Molecular Weight | 400.5925 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2093867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3155733 |
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Target ID: P16233 Gene ID: 5406.0 Gene Symbol: PNLIP Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/25466463 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2743335
1,2-Didecanoylglycerol (glyceryl 1,2-dicaprate) was evaluated as a complete skin tumor promoter in CD-1 mice : mice were initiated with 200 nmol 7,12-dimethylbenz[a]anthracene. One week later the mice received twice daily topical applications of 1 nmol TPA, 2 mumol sn-1,2-didecanoylglycerol or 5 mumol sn-1,2-didecanoylglycerol, 5 days/week.
Route of Administration:
Transdermal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2992914
ACTH and beta-endorphin (beta-End) secretion were enhanced by 1,2-didecanoylglycerol (glyceryl 1,2-dicaprate/DiC10) in a concentration-dependent manner, with a minimal effective concentration of 5 microM. The effect of DiC10 was time dependent, with maximal responses occurring at 15-30. Release of GH was also enhanced significantly by DiC10 with minimal effective concentrations of 1 microM. In additional experiments, the effects of DiC10 on secretion of LH, FSH, PRL, and TSH were evaluated. The results indicate that 5-25 microM DiC10 produced a concentration-dependent release of each of those hormones.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:44:05 GMT 2023
by
admin
on
Fri Dec 15 16:44:05 GMT 2023
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Record UNII |
D5K11SW7QP
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Record Status |
Validated (UNII)
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Record Version |
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-
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D5K11SW7QP
Created by
admin on Fri Dec 15 16:44:05 GMT 2023 , Edited by admin on Fri Dec 15 16:44:05 GMT 2023
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Created by
admin on Fri Dec 15 16:44:05 GMT 2023 , Edited by admin on Fri Dec 15 16:44:05 GMT 2023
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