U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H23ClN4O2
Molecular Weight 326.822
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAZOPRIDE

SMILES

CCN1CC(CN1CC)NC(=O)C2=C(OC)C=C(N)C(Cl)=C2

InChI

InChIKey=YFXIKEZOBJFVAQ-UHFFFAOYSA-N
InChI=1S/C15H23ClN4O2/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21)

HIDE SMILES / InChI
Dazopride is an antagonist of the 5-HT3 receptor and agonist of the 5-HT4 receptor, structurally related to metoclopramide. Dazopride was developed by A. H. Robins Company as an antiemetic and gastroprokinetic drug. Dazoptide demonstrated an antiemetic effect in the clinic after i.v. infusion to patients, receiving anticancer therapy.

Approval Year

Patents

Patents

Sample Use Guides

i.v. infusions every 2 h beginning 30 min before the chemotherapy at doses 0.5 to 4.0 mg/kg.
Route of Administration: Intravenous
Name Type Language
DAZOPRIDE
INN   WHO-DD  
INN  
Official Name English
4-AMINO-5-CHLORO-N-(1,2-DIETHYL-4-PYRAZOLIDINYL)-O-ANISAMIDE
Common Name English
dazopride [INN]
Common Name English
Dazopride [WHO-DD]
Common Name English
BENZAMIDE, 4-AMINO-5-CHLORO-N-(1,2-DIETHYL-4-PYRAZOLIDINYL)-2-METHOXY-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C267
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID80867875
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
EVMPD
SUB06923MIG
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
FDA UNII
CV07VSP2G8
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
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MESH
C047339
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
INN
5415
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110810
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
CAS
70181-03-2
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
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NCI_THESAURUS
C72732
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
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WIKIPEDIA
Dazopride
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
SMS_ID
100000083447
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY
PUBCHEM
54801
Created by admin on Fri Dec 15 15:39:10 GMT 2023 , Edited by admin on Fri Dec 15 15:39:10 GMT 2023
PRIMARY