Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H23ClN4O2 |
Molecular Weight | 326.822 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1CC(CN1CC)NC(=O)C2=C(OC)C=C(N)C(Cl)=C2
InChI
InChIKey=YFXIKEZOBJFVAQ-UHFFFAOYSA-N
InChI=1S/C15H23ClN4O2/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21)
Dazopride is an antagonist of the 5-HT3 receptor and agonist of the 5-HT4 receptor, structurally related to metoclopramide. Dazopride was developed by A. H. Robins Company as an antiemetic and gastroprokinetic drug. Dazoptide demonstrated an antiemetic effect in the clinic after i.v. infusion to patients, receiving anticancer therapy.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8453682
i.v. infusions every 2 h beginning 30 min before the chemotherapy at doses 0.5 to 4.0 mg/kg.
Route of Administration:
Intravenous
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NCI_THESAURUS |
C267
Created by
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DTXSID80867875
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SUB06923MIG
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CV07VSP2G8
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C047339
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5415
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CHEMBL2110810
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70181-03-2
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C72732
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Dazopride
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100000083447
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54801
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)