U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H14Cl4N2O
Molecular Weight 416.129
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MICONAZOLE, (R)-

SMILES

ClC1=CC(Cl)=C(CO[C@@H](CN2C=CN=C2)C3=C(Cl)C=C(Cl)C=C3)C=C1

InChI

InChIKey=BYBLEWFAAKGYCD-SFHVURJKSA-N
InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2/t18-/m0/s1

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo controlled trial of miconazole nitrate 0.25%.
2001 Mar-Apr
Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing.
2003 Oct 2
[Screening Examination and Management of Dermatophytosis by Trichophyton tonsurans in the Judo Club of a University].
2004
Vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insert.
2004 Feb
The contraceptive vaginal ring, NuvaRing, and antimycotic co-medication.
2004 Feb
Structure and generation mechanism of a novel degradation product formed by oxidatively induced coupling of miconazole nitrate with butylated hydroxytoluene in a topical ointment studied by HPLC-ESI-MS and organic synthesis.
2004 Feb
Miconazole nitrate: comprehensive profile.
2005
Topical miconazole nitrate ointment in the treatment of diaper dermatitis complicated by candidiasis.
2006 Feb
Anti-inflammatory and anti-itch activity of sertaconazole nitrate.
2006 Sep
Species distribution and susceptibility to azoles of vaginal yeasts isolated prostitutes.
2007
Safety study of an antimicrobial peptide lactocin 160, produced by the vaginal Lactobacillus rhamnosus.
2007
Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection.
2008
Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study.
2008 Nov
Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis.
2008 Sep
Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery.
2009
Development and validation of a simple stability-indicating high performance liquid chromatographic method for the determination of miconazole nitrate in bulk and cream formulations.
2009 Aug 15
Sertaconazole 2% cream vs. miconazole 2% cream for cutaneous mycoses: a double-blind clinical trial.
2009 Dec
Antioxidant, Antimicrobial Activity and Toxicity Test of Pilea microphylla.
2010
Prevention and treatment of intertrigo in large skin folds of adults: a systematic review.
2010 Jul 13
Formulation and evaluation of mucoadhesive buccal films of enalapril maleate.
2010 Sep
Structure-activity studies and therapeutic potential of host defense peptides of human thrombin.
2011 Jun
Patents
Name Type Language
MICONAZOLE, (R)-
Common Name English
MICONAZOLE, (-)-
Common Name English
1H-IMIDAZOLE, 1-((2R)-2-(2,4-DICHLOROPHENYL)-2-((2,4-DICHLOROPHENYL)METHOXY)ETHYL)-
Systematic Name English
Code System Code Type Description
PUBCHEM
1150344
Created by admin on Sat Dec 16 11:16:02 GMT 2023 , Edited by admin on Sat Dec 16 11:16:02 GMT 2023
PRIMARY
CAS
47447-53-0
Created by admin on Sat Dec 16 11:16:02 GMT 2023 , Edited by admin on Sat Dec 16 11:16:02 GMT 2023
PRIMARY
FDA UNII
C90U92KSVX
Created by admin on Sat Dec 16 11:16:02 GMT 2023 , Edited by admin on Sat Dec 16 11:16:02 GMT 2023
PRIMARY