Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H14Cl4N2O |
| Molecular Weight | 416.129 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(CO[C@@H](CN2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C(Cl)=C1
InChI
InChIKey=BYBLEWFAAKGYCD-SFHVURJKSA-N
InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2/t18-/m0/s1
| Molecular Formula | C18H14Cl4N2O |
| Molecular Weight | 416.129 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Structure-activity studies and therapeutic potential of host defense peptides of human thrombin. | 2011-06 |
|
| Formulation and evaluation of mucoadhesive buccal films of enalapril maleate. | 2010-09 |
|
| Synergistic effect of hydroxypropyl-beta-cyclodextrin encapsulated soluble ferrocene and the gold nanocomposite modified glassy carbon electrode for the estimation of NO in biological systems. | 2010-09 |
|
| Synthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents. | 2010-09 |
|
| Design and development of solid lipid nanoparticles for topical delivery of an anti-fungal agent. | 2010-08 |
|
| Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability. | 2010-07-27 |
|
| Prevention and treatment of intertrigo in large skin folds of adults: a systematic review. | 2010-07-13 |
|
| Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies. | 2010-06-11 |
|
| Antioxidant, Antimicrobial Activity and Toxicity Test of Pilea microphylla. | 2010 |
|
| Sertaconazole 2% cream vs. miconazole 2% cream for cutaneous mycoses: a double-blind clinical trial. | 2009-12 |
|
| Development and validation of a simple stability-indicating high performance liquid chromatographic method for the determination of miconazole nitrate in bulk and cream formulations. | 2009-08-15 |
|
| L(9) orthogonal design assisted formulation and evaluation of chitosan-based buccoadhesive films of miconazole nitrate. | 2009-07 |
|
| Simultaneous determination of metronidazole and miconazole nitrate in gel by HPTLC. | 2009-07 |
|
| Development of Buccal Adhesive Tablet with Prolonged Antifungal activity: Optimization and ex vivo Deposition Studies. | 2009-05 |
|
| Evidence-based veterinary dermatology: a systematic review of interventions for Malassezia dermatitis in dogs. | 2009-02 |
|
| Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. | 2009 |
|
| Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. | 2008-11 |
|
| Preliminary isolation and in vitro antiyeast activity of active fraction from crude extract of Gracilaria changii. | 2008-10 |
|
| [Clinical effect and safety of miconazole nitrate 1200 mg in treating vulvovaginal candidiasis]. | 2008-10 |
|
| Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. | 2008-09 |
|
| Reconstructed interfollicular feline epidermis as a model for the screening of antifungal drugs against Microsporum canis. | 2008-06 |
|
| Stability indicating methods for the determination of some anti-fungal agents using densitometric and RP-HPLC methods. | 2008-02 |
|
| Positively charged microemulsions for topical application. | 2008-01-04 |
|
| Spermicidal activity of the safe natural antimicrobial peptide subtilosin. | 2008 |
|
| Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection. | 2008 |
|
| The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg). | 2007-06 |
|
| Absorption and efficacy of miconazole nitrate 0.25% ointment in infants with diaper dermatitis. | 2007-05 |
|
| [How I treat....A stoutness-associated intertrigo]. | 2007-02 |
|
| Species distribution and susceptibility to azoles of vaginal yeasts isolated prostitutes. | 2007 |
|
| Safety study of an antimicrobial peptide lactocin 160, produced by the vaginal Lactobacillus rhamnosus. | 2007 |
|
| Trichophyton violaceum: a rare isolate in 18-day-old neonate. | 2006-10 |
|
| Anti-inflammatory and anti-itch activity of sertaconazole nitrate. | 2006-09 |
|
| Intrasperm Ca2+ modulation and human ejaculated sperm viability: influence of miconazole, clotrimazole and loperamide. | 2006-08 |
|
| Effect of a single overnight topical application of miconazole nitrate paste on acne papules. | 2006-03 |
|
| Topical miconazole nitrate ointment in the treatment of diaper dermatitis complicated by candidiasis. | 2006-02 |
|
| PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole. | 2006-02 |
|
| Dynamics of skin barrier repair following topical applications of miconazole nitrate. | 2006 |
|
| Safety and efficacy of bedtime versus daytime administration of the miconazole nitrate 1200 mg vaginal ovule insert to treat vulvovaginal candidiasis. | 2005-01 |
|
| Miconazole nitrate: comprehensive profile. | 2005 |
|
| [Evaluation of the efficacy of miconazole nitrate shampoo for prevention against T. tonsurans infection]. | 2005 |
|
| Difference in percutaneous absorption and intracutaneous distribution in guinea pigs among topical antifungal drugs (tioconazole solution, tioconazole cream, miconazole nitrate solution and bifonazole solution). | 2004-09 |
|
| Surrogate nits impregnated with white piedra--a case report. | 2004-07 |
|
| Comparative efficacy of topical therapy with a slow-release mucoadhesive buccal tablet containing miconazole nitrate versus systemic therapy with ketoconazole in HIV-positive patients with oropharyngeal candidiasis. | 2004-02-01 |
|
| Vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insert. | 2004-02 |
|
| The contraceptive vaginal ring, NuvaRing, and antimycotic co-medication. | 2004-02 |
|
| Structure and generation mechanism of a novel degradation product formed by oxidatively induced coupling of miconazole nitrate with butylated hydroxytoluene in a topical ointment studied by HPLC-ESI-MS and organic synthesis. | 2004-02 |
|
| [Screening Examination and Management of Dermatophytosis by Trichophyton tonsurans in the Judo Club of a University]. | 2004 |
|
| Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing. | 2003-10-02 |
|
| Preparation and in vitro/in vivo evaluation of the buccal bioadhesive properties of slow-release tablets containing miconazole nitrate. | 2003-03 |
|
| Comparison of dermatopharmacokinetic vs. clinicial efficacy methods for bioequivalence assessment of miconazole nitrate vaginal cream, 2% in humans. | 2002-03 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:43:39 GMT 2025
by
admin
on
Mon Mar 31 23:43:39 GMT 2025
|
| Record UNII |
C90U92KSVX
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Name | Type | Language | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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1150344
Created by
admin on Mon Mar 31 23:43:39 GMT 2025 , Edited by admin on Mon Mar 31 23:43:39 GMT 2025
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PRIMARY | |||
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47447-53-0
Created by
admin on Mon Mar 31 23:43:39 GMT 2025 , Edited by admin on Mon Mar 31 23:43:39 GMT 2025
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PRIMARY | |||
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C90U92KSVX
Created by
admin on Mon Mar 31 23:43:39 GMT 2025 , Edited by admin on Mon Mar 31 23:43:39 GMT 2025
|
PRIMARY |
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|---|---|---|---|---|
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RACEMATE -> ENANTIOMER |
