Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8N4O3 |
| Molecular Weight | 196.1634 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C2=C(NC(=O)N2)C(=O)N(C)C1=O
InChI
InChIKey=OTSBKHHWSQYEHK-UHFFFAOYSA-N
InChI=1S/C7H8N4O3/c1-10-4-3(8-6(13)9-4)5(12)11(2)7(10)14/h1-2H3,(H2,8,9,13)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Theophylline metabolism: variation and genetics. | 1984 Feb |
|
| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995 Nov 9 |
|
| Neurotoxic convulsions induced by theophylline and its metabolites in mice. | 1996 Jun |
|
| Caffeine metabolism before and after liver transplantation. | 2001 Feb |
|
| Effect of alosetron on theophylline pharmacokinetics. | 2001 Nov |
|
| Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats. | 2003 Jan 31 |
|
| Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. | 2005 Jul |
|
| Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. | 2005 Sep |
|
| Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. | 2006 Aug |
|
| Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine. | 2006 May |
|
| Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats. | 2006 May 30 |
|
| Theophylline and its metabolites produce a stimulating cholinergic effect on the small intestine and a nonadrenergic noncholinergic relaxing effect on the colon: a comparative study in the rabbit intestine. | 2007 Dec |
|
| Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. | 2008 Jan |
|
| Relaxing and contracting effects of theophylline's metabolites on the rabbit upper gastrointestinal tract. | 2008 Oct |
|
| Demethylation of theophylline (1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. | 2010 |
|
| A synthetic uric acid analog accelerates cutaneous wound healing in mice. | 2010 Apr 6 |
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DTXSID50241466
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213-410-1
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68447
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95854
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C031274
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70346
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944-73-0
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C222JTI9I3
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PARENT (METABOLITE INACTIVE)
SUBSTANCE RECORD
