Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8N4O3 |
| Molecular Weight | 196.1634 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C2=C(NC(=O)N2)C(=O)N(C)C1=O
InChI
InChIKey=OTSBKHHWSQYEHK-UHFFFAOYSA-N
InChI=1S/C7H8N4O3/c1-10-4-3(8-6(13)9-4)5(12)11(2)7(10)14/h1-2H3,(H2,8,9,13)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995 Nov 9 |
|
| Neurotoxic convulsions induced by theophylline and its metabolites in mice. | 1996 Jun |
|
| Caffeine metabolism before and after liver transplantation. | 2001 Feb |
|
| Catabolism of caffeine in plants and microorganisms. | 2004 May 1 |
|
| Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. | 2005 Jul |
|
| Inhibition of theophylline metabolism by suplatast and its metabolites in rats. | 2005 Jun |
|
| Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. | 2005 Sep |
|
| Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine. | 2006 May |
|
| Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats. | 2006 May 30 |
|
| Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats. | 2007 Mar |
|
| Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. | 2007 Nov |
|
| Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. | 2008 Apr |
|
| Time-dependent effects of Klebsiella pneumoniae endotoxin (KPLPS) on the pharmacokinetics of theophylline in rats: return of the parameters in 96-hour KPLPS rats to the control levels. | 2008 May |
|
| Relaxing and contracting effects of theophylline's metabolites on the rabbit upper gastrointestinal tract. | 2008 Oct |
|
| Nitrosation of N-methyl derivatives of uric acid and their transnitrosation ability to N-acetylcysteine. | 2010 Sep |
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DTXSID50241466
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213-410-1
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68447
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95854
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C031274
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70346
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944-73-0
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C222JTI9I3
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PARENT (METABOLITE INACTIVE)
SUBSTANCE RECORD
