Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H8N4O3 |
Molecular Weight | 196.1634 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C2=C(NC(=O)N2)C(=O)N(C)C1=O
InChI
InChIKey=OTSBKHHWSQYEHK-UHFFFAOYSA-N
InChI=1S/C7H8N4O3/c1-10-4-3(8-6(13)9-4)5(12)11(2)7(10)14/h1-2H3,(H2,8,9,13)
Molecular Formula | C7H8N4O3 |
Molecular Weight | 196.1634 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Theophylline metabolism: variation and genetics. | 1984 Feb |
|
Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease. | 1988 Sep |
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Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995 Nov 9 |
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Neurotoxic convulsions induced by theophylline and its metabolites in mice. | 1996 Jun |
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Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin. | 2001 Aug 15 |
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Caffeine metabolism before and after liver transplantation. | 2001 Feb |
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Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis. | 2001 Jan |
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Dose dependent pharmacokinetics of theophylline: Michaelis-Menten parameters for its major metabolic pathways. | 2001 Jan-Jun |
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Effect of alosetron on theophylline pharmacokinetics. | 2001 Nov |
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Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. | 2002 Dec |
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Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats. | 2003 Jan 31 |
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Catabolism of caffeine in plants and microorganisms. | 2004 May 1 |
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Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples. | 2004 Oct |
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Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). | 2005 Mar |
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Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. | 2006 Aug |
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Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine. | 2006 May |
|
7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands. | 2007 Aug 1 |
|
Theophylline and its metabolites produce a stimulating cholinergic effect on the small intestine and a nonadrenergic noncholinergic relaxing effect on the colon: a comparative study in the rabbit intestine. | 2007 Dec |
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Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats. | 2007 Mar |
|
Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. | 2007 Nov |
|
Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. | 2008 Apr |
|
[Population pharmacokinetic analysis of two theophylline formulations in premature neonates and infants with apnea]. | 2008 Apr |
|
Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. | 2008 Jan |
|
Time-dependent effects of Klebsiella pneumoniae endotoxin (KPLPS) on the pharmacokinetics of theophylline in rats: return of the parameters in 96-hour KPLPS rats to the control levels. | 2008 May |
|
Relaxing and contracting effects of theophylline's metabolites on the rabbit upper gastrointestinal tract. | 2008 Oct |
|
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. | 2009 Jul |
|
Demethylation of theophylline (1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. | 2010 |
|
A synthetic uric acid analog accelerates cutaneous wound healing in mice. | 2010 Apr 6 |
|
Nitrosation of N-methyl derivatives of uric acid and their transnitrosation ability to N-acetylcysteine. | 2010 Sep |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:36:15 GMT 2023
by
admin
on
Fri Dec 15 18:36:15 GMT 2023
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Record UNII |
C222JTI9I3
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID50241466
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213-410-1
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68447
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C031274
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70346
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C222JTI9I3
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admin on Fri Dec 15 18:36:15 GMT 2023 , Edited by admin on Fri Dec 15 18:36:15 GMT 2023
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