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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27NO2.ClH
Molecular Weight 373.916
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINEPTINE HYDROCHLORIDE

SMILES

Cl.OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3

InChI

InChIKey=VDPUXONTAVMIKZ-UHFFFAOYSA-N
InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H

HIDE SMILES / InChI

Description

Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Survector

Approved Use

Survector 100mg tablet is used in the treatment of depression.

Launch Date

1977
PubMed

PubMed

TitleDatePubMed
[Amineptin-induced hepatitis: differential diagnosis of biliary microlithiasis].
1982 Nov
[Acneiform eruption induced by amineptin (Survector)].
1989
[Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case].
1991 Dec
The serotonin syndrome.
1992 Oct
[Acne induced by amineptin: adnexal toxiderma].
1996
WHO Expert Committee on Drug Dependence. Thirty-second report.
2001
Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction.
2001
Acneiform eruption caused by amineptine. A case report and review of the literature.
2001 Jul
Social stress in anorexia nervosa: a review of immuno-endocrine relationships.
2001 Jun
Observation of psychoactive substance consumption: methods and results of the French OPPIDUM programme.
2001 Mar
WHO Expert Committee on Drug Dependence.
2003
Discriminating different classes of toxicants by transcript profiling.
2004 Aug
Sex-dependent modulation of treatment response.
2004 Mar
Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse.
2008 Sep
Improving pain management communication: how patients understand the terms "opioid" and "narcotic".
2008 Sep
Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability.
2009
Spectroscopic and electrochemical analysis of psychotropic drugs.
2009 Jan
Prevalence of antidepressants and biosimilars in elite sport.
2009 Jun
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Patents

US8158152
7

Sample Use Guides

In Vivo Use Guide
Sources: www.ncbi.nlm.nih.gov/pubmed/21584062
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration: Oral
In Vitro Use Guide
Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.
Name Type Language
AMINEPTINE HYDROCHLORIDE
MART.   MI   WHO-DD  
Common Name English
HEPTANOIC ACID, 7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)-, HYDROCHLORIDE (1:1)
Common Name English
AMINEPTINE HYDROCHLORIDE [MART.]
Common Name English
7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)HEPTANOIC ACID MONOHYDROCHLORIDE
Systematic Name English
SURVECTOR
Brand Name English
S-1694
Code English
AMINEPTINE HCL
Common Name English
AMINEPTINE HYDROCHLORIDE [MI]
Common Name English
MANEON
Brand Name English
Amineptine hydrochloride [WHO-DD]
Common Name English
AMINEPTENE HYDROCHLORIDE
Common Name English
Code System Code Type Description
CHEBI
32499
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
ECHA (EC/EINECS)
250-107-3
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
DRUG BANK
DBSALT000803
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
EVMPD
SUB00447MIG
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
CAS
30272-08-3
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
FDA UNII
A5P604A12R
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
MERCK INDEX
m1673
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID20952633
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
SMS_ID
100000085152
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
PUBCHEM
34869
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
CHEBI
50003
Created by admin on Fri Dec 15 17:00:55 GMT 2023 , Edited by admin on Fri Dec 15 17:00:55 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of AMINEPTINE
NIH
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