PREZATIDE COPPER ACETATE

First approved in 2011

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C14H24N6O4.2C2H3O2.Cu
Molecular Weight	862.39
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cu++].CC([O-])=O.CC([O-])=O.NCCCC[C@H](NC(=O)[C@H](CC1=CNC=N1)NC(=O)CN)C(O)=O.NCCCC[C@H](NC(=O)[C@H](CC2=CNC=N2)NC(=O)CN)C(O)=O

InChI

InChIKey=LUNQZVCDZKODKF-PFVVTREHSA-L

InChI=1S/2C14H24N6O4.2C2H4O2.Cu/c2*15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;2*1-2(3)4;/h2*7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);2*1H3,(H,3,4);/q;;;;+2/p-2/t2*10-,11-;;;/m00.../s1

HIDE SMILES / InChI

Description
Sources: https://www.drugbank.ca/drugs/DB11296 | https://www.ncbi.nlm.nih.gov/pubmed/26236730 | https://www.drugbank.ca/drugs/DB11296#reference-A19503

Prezatide is a tripeptide molecule consisiting of lysine, glycine and histidine, also known as GHK (glycyl-L-histidyl-L-lysine), that forms a complex with copper ions. Prezatide is used in cosmetic products (skin and hair) and is known help wound healing. Prezatide increases the synthesis and deposition of type I collagen and glycosaminoglycan. It is thought to play a role in the modulation of tissue remodeling by increases the expression of matrix metalloproteinase-2, as well as tissue inhibitor of matrix metalloproteinases-1 and -2. Prezatide has antioxidant activity due to its ability to supply copper for superoxide dismutase and anti-inflammatory ability due to the blockage the of iron (Fe2+) release during injury.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburns 22 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8276be2-93f1-4782-b206-93ea31036216	Inactive ingredient		Approved 8429	Volu-Firm Approved Use Unknown

Name

Type

Language

PREZATIDE COPPER ACETATE

Official Name

English

GHK BIS COMPLEX WITH COPPER DIACETATE

Common Name

English

BIS(TRIPEPTIDE-1) COPPER ACETATE [INCI]

Common Name

English

IAMIN

Brand Name

English

GHK BIS COMPLEX WITH COPPER DIACETATE [MI]

Common Name

English

PREZATIDE COPPER ACETATE [MART.]

Common Name

English

PC1020 ACETATE

Code

English

PREZATIDE COPPER ACETATE [USAN]

Common Name

English

CUPRATE (1-), (N(SUP 2)-(N-GLYCYL-L-HISTIDYL)-L-LYSINATO)(N(SUP 2)-(N-GLYCYL-L-HISTIDYL)-L-LYSINATO(2-))-, HYDROGEN, DIACETATE

Systematic Name

English

BIS(TRIPEPTIDE-1) COPPER ACETATE

Official Name

English

PC-1020

Code

English

CUPRATE(1-), (GLYCYL-L-HISTIDYL-.KAPPA.N1-L-LYSINATO)(GLYCYL-.KAPPA.N-L-HISTIDYL-.KAPPA.N,.KAPPA.N3-L-LYSINATO(2-))-, HYDROGEN, ACETATE (1:1:2)

Systematic Name

English

PC-1020 ACETATE

Code

English

prezatide copper acetate [INN]

Common Name

English

Prezatide copper acetate [WHO-DD]

Common Name

English

TRIPEPTIDE-1 COPPER ACETATE

Common Name

English

Code System Code Type Description

SMS_ID

100000081611