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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C14H24N6O4.2C2H3O2.Cu
Molecular Weight 862.39
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PREZATIDE COPPER ACETATE

SMILES

[Cu++].CC([O-])=O.CC([O-])=O.NCCCC[C@H](NC(=O)[C@H](CC1=CNC=N1)NC(=O)CN)C(O)=O.NCCCC[C@H](NC(=O)[C@H](CC2=CNC=N2)NC(=O)CN)C(O)=O

InChI

InChIKey=LUNQZVCDZKODKF-PFVVTREHSA-L
InChI=1S/2C14H24N6O4.2C2H4O2.Cu/c2*15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;2*1-2(3)4;/h2*7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);2*1H3,(H,3,4);/q;;;;+2/p-2/t2*10-,11-;;;/m00.../s1

HIDE SMILES / InChI
Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C14H23N6O4
Molecular Weight 339.3702
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C2H3O2
Molecular Weight 59.044
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Prezatide is a tripeptide molecule consisiting of lysine, glycine and histidine, also known as GHK (glycyl-L-histidyl-L-lysine), that forms a complex with copper ions. Prezatide is used in cosmetic products (skin and hair) and is known help wound healing. Prezatide increases the synthesis and deposition of type I collagen and glycosaminoglycan. It is thought to play a role in the modulation of tissue remodeling by increases the expression of matrix metalloproteinase-2, as well as tissue inhibitor of matrix metalloproteinases-1 and -2. Prezatide has antioxidant activity due to its ability to supply copper for superoxide dismutase and anti-inflammatory ability due to the blockage the of iron (Fe2+) release during injury.

Approval Year

2011
587
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Approved
8429
Volu-Firm

Approved Use

Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:38 GMT 2023
Edited
by admin
on Fri Dec 15 15:52:38 GMT 2023
Record UNII
A3LEI4P1NB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PREZATIDE COPPER ACETATE
INN   MART.   USAN   WHO-DD  
USAN   INN  
Official Name English
GHK BIS COMPLEX WITH COPPER DIACETATE
MI  
Common Name English
BIS(TRIPEPTIDE-1) COPPER ACETATE [INCI]
Common Name English
IAMIN
Brand Name English
GHK BIS COMPLEX WITH COPPER DIACETATE [MI]
Common Name English
PREZATIDE COPPER ACETATE [MART.]
Common Name English
PC1020 ACETATE
Code English
PREZATIDE COPPER ACETATE [USAN]
Common Name English
CUPRATE (1-), (N(SUP 2)-(N-GLYCYL-L-HISTIDYL)-L-LYSINATO)(N(SUP 2)-(N-GLYCYL-L-HISTIDYL)-L-LYSINATO(2-))-, HYDROGEN, DIACETATE
Systematic Name English
BIS(TRIPEPTIDE-1) COPPER ACETATE
INCI  
INCI  
Official Name English
PC-1020
Code English
CUPRATE(1-), (GLYCYL-L-HISTIDYL-.KAPPA.N1-L-LYSINATO)(GLYCYL-.KAPPA.N-L-HISTIDYL-.KAPPA.N,.KAPPA.N3-L-LYSINATO(2-))-, HYDROGEN, ACETATE (1:1:2)
Systematic Name English
PC-1020 ACETATE
Code English
prezatide copper acetate [INN]
Common Name English
Prezatide copper acetate [WHO-DD]
Common Name English
TRIPEPTIDE-1 COPPER ACETATE
Common Name English
Code System Code Type Description
SMS_ID
100000081611
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
DRUG BANK
DBSALT002420
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
USAN
CC-72
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
MERCK INDEX
m5722
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY Merck Index
RXCUI
1314596
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY RxNorm
DAILYMED
A3LEI4P1NB
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
CAS
130120-57-9
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
INN
6955
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
EVMPD
SUB10033MIG
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
FDA UNII
A3LEI4P1NB
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID00156359
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
NCI_THESAURUS
C171726
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
PUBCHEM
9876021
Created by admin on Fri Dec 15 15:52:39 GMT 2023 , Edited by admin on Fri Dec 15 15:52:39 GMT 2023
PRIMARY
Related Record Type Details
Structure of CUPRIC CATION
PARENT -> SALT/SOLVATE
Structure of PREZATIDE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of PREZATIDE
ACTIVE MOIETY
NIH
NCATS
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HHS VULNERABILITY DISCLOSURE
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