Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C21H29NO |
| Molecular Weight | 311.4611 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2C(C)(C)C
InChI
InChIKey=OGNRRAFRDFGFKA-UHFFFAOYSA-N
InChI=1S/C21H29NO/c1-21(2,3)19-14-10-9-13-18(19)20(23-16-15-22(4)5)17-11-7-6-8-12-17/h6-14,20H,15-16H2,1-5H3
Bufenadrine is a derivative of diphenhydramine. The compound was originally developed as an anti-motion sickness drug. Prolonged toxicity studies in rats, however, showed liver toxicity, and no further clinical evaluation was undertaken. Investigation of the metabolism showed that (-)-bufenadrine was enantiomer, exclusively responsible for toxic activities of the racemic compound.
Approval Year
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NCI_THESAURUS |
C29578
Created by
admin on Sat Dec 16 17:55:22 GMT 2023 , Edited by admin on Sat Dec 16 17:55:22 GMT 2023
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9Y0T619B3U
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604-74-0
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DTXSID70862278
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1385
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C73046
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CHEMBL2104614
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21916
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SUB05959MIG
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100000088455
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
