SODIUM BROMEBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H8BrO4.Na
Molecular Weight	307.073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].COC1=CC=C(C=C1)C(=O)C(\Br)=C/C([O-])=O

InChI

InChIKey=DVDCIQWIGOVWEX-MLBSPLJJSA-M

InChI=1S/C11H9BrO4.Na/c1-16-8-4-2-7(3-5-8)11(15)9(12)6-10(13)14;/h2-6H,1H3,(H,13,14);/q;+1/p-1/b9-6+;

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2169015 | https://www.ncbi.nlm.nih.gov/pubmed/6897625 | https://www.ncbi.nlm.nih.gov/pubmed/6189445

Bromebric Acid (Cytembena) is a derivative of bromoacrylic acid with cytostatic and antineoplastic activity. Chemical structure of Bromebric Acid is not related to any previous antineoplastic agent. In animal tumor screens, Jelinek and Semonsky noted antineoplastic activity of Cytembena against sarcoma 180, atlenocarcinoina of the lactic gland in mice, Ehrlich’s ascitic carcinoma, Yoshida’s ascitic sarcoma, and Zojdeln’s heap

Originator

Approval Year

PubMed

Title	Date	PubMed
Doxorubicin, vincristine, bleomycin, cytembena and cisplatin as combination chemotherapy for squamous cell lung cancer.	1983-03-01	6189445
Cytembena and cis-platinum in combination for advanced stage ovarian carcinoma treatment.	1982	6897625

Patents

Name

Type

Language

CYTEMBENA

Preferred Name

English

SODIUM BROMEBRATE

Common Name

English

NSC-104801

Code

English

BROMEBRIC ACID SODIUM SALT

Common Name

English

CYTEMBENE

Brand Name

English

2-BUTENOIC ACID, 3-BROMO-4-(4-METHOXYPHENYL)-4-OXO-, SODIUM SALT (1:1), (2E)-

Systematic Name

English

(E)-3-(P-ANISOYL)-3-BROMOACRYLIC ACID, SODIUM SALT

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C272