BROMEBRIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H9BrO4
Molecular Weight	285.091
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C(=O)C(\Br)=C/C(O)=O

InChI

InChIKey=UPZFHUODAYGHDZ-RMKNXTFCSA-N

InChI=1S/C11H9BrO4/c1-16-8-4-2-7(3-5-8)11(15)9(12)6-10(13)14/h2-6H,1H3,(H,13,14)/b9-6+

HIDE SMILES / InChI

Molecular Formula	C11H9BrO4
Molecular Weight	285.091
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2169015 | https://www.ncbi.nlm.nih.gov/pubmed/6897625 | https://www.ncbi.nlm.nih.gov/pubmed/6189445

Bromebric Acid (Cytembena) is a derivative of bromoacrylic acid with cytostatic and antineoplastic activity. Chemical structure of Bromebric Acid is not related to any previous antineoplastic agent. In animal tumor screens, Jelinek and Semonsky noted antineoplastic activity of Cytembena against sarcoma 180, atlenocarcinoina of the lactic gland in mice, Ehrlich’s ascitic carcinoma, Yoshida’s ascitic sarcoma, and Zojdeln’s heap

Originator

Approval Year

PubMed

Title	Date	PubMed
Cytembena and cis-platinum in combination for advanced stage ovarian carcinoma treatment.	1982	6897625
Doxorubicin, vincristine, bleomycin, cytembena and cisplatin as combination chemotherapy for squamous cell lung cancer.	1983 Mar-Apr	6189445

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:12:39 GMT 2023` Edited by `admin` on `Sat Dec 16 17:12:39 GMT 2023`
Record UNII	FGE8818GWA
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BROMEBRIC ACID

Official Name

English

(E)-3-(P-ANISOYL)-3-BROMOACRYLIC ACID

Common Name

English

(E)-3-P-ANISOYL-3-BROMOACRYLIC ACID

Common Name

English

bromebric acid [INN]

Common Name

English

2-BUTENOIC ACID, 3-BROMO-4-(4-METHOXYPHENYL)-4-OXO-, (2E)-

Systematic Name

English

NSC-265480

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C272