SODIUM BROMEBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H8BrO4.Na
Molecular Weight	307.073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].COC1=CC=C(C=C1)C(=O)C(\Br)=C/C([O-])=O

InChI

InChIKey=DVDCIQWIGOVWEX-MLBSPLJJSA-M

InChI=1S/C11H9BrO4.Na/c1-16-8-4-2-7(3-5-8)11(15)9(12)6-10(13)14;/h2-6H,1H3,(H,13,14);/q;+1/p-1/b9-6+;

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C11H8BrO4
Molecular Weight	284.083
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2169015 | https://www.ncbi.nlm.nih.gov/pubmed/6897625 | https://www.ncbi.nlm.nih.gov/pubmed/6189445

Bromebric Acid (Cytembena) is a derivative of bromoacrylic acid with cytostatic and antineoplastic activity. Chemical structure of Bromebric Acid is not related to any previous antineoplastic agent. In animal tumor screens, Jelinek and Semonsky noted antineoplastic activity of Cytembena against sarcoma 180, atlenocarcinoina of the lactic gland in mice, Ehrlich’s ascitic carcinoma, Yoshida’s ascitic sarcoma, and Zojdeln’s heap

Originator

Approval Year

PubMed

Title	Date	PubMed
Cytembena and cis-platinum in combination for advanced stage ovarian carcinoma treatment.	1982	6897625
Doxorubicin, vincristine, bleomycin, cytembena and cisplatin as combination chemotherapy for squamous cell lung cancer.	1983 Mar-Apr	6189445

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:25:19 GMT 2023` Edited by `admin` on `Sat Dec 16 09:25:19 GMT 2023`
Record UNII	9V238C7BMX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM BROMEBRATE

Common Name

English

NSC-104801

Code

English

CYTEMBENA

Brand Name

English

BROMEBRIC ACID SODIUM SALT

Common Name

English

CYTEMBENE

Brand Name

English

2-BUTENOIC ACID, 3-BROMO-4-(4-METHOXYPHENYL)-4-OXO-, SODIUM SALT (1:1), (2E)-

Systematic Name

English

(E)-3-(P-ANISOYL)-3-BROMOACRYLIC ACID, SODIUM SALT

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C272