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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H41NO6.ClH
Molecular Weight 512.078
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCORTAMATE HYDROCHLORIDE

SMILES

Cl.CCN(CC)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

InChI

InChIKey=AKQNAIYKSALPKV-OYHXESGYSA-N
InChI=1S/C27H41NO6.ClH/c1-5-28(6-2)15-23(32)34-16-22(31)27(33)12-10-20-19-8-7-17-13-18(29)9-11-25(17,3)24(19)21(30)14-26(20,27)4;/h13,19-21,24,30,33H,5-12,14-16H2,1-4H3;1H/t19-,20-,21-,24+,25-,26-,27-;/m0./s1

HIDE SMILES / InChI

Description

Hydrocortamate is a synthetic glucocorticoid possessing anti-inflammatory properties and acting as a glucocorticoid receptor agonist. Hydrocortamate was used under the brand name Magnacor to treat inflammation due to corticosteroid-responsive dermatoses btut that usage has been discontinued.

Approval Year

1956
94
Targets

Targets

Primary TargetPharmacologyConditionPotency
Glucocorticoid receptor
173
Target ID: CHEMBL2034
Agonist
2752
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8583
MAGNACORT

Approved Use

Unknown
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1946

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP3A4
1946
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:50851
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50851
ZINC
ZINC000004213506
http://zinc15.docking.org/substances/ZINC000004213506
PubMed

PubMed

TitleDatePubMed
[On the topical use of a new pharmacological association of enzymes, neomycin and hydrocortamate. Clinical contribution].
1965-11
Hydrocortamate (magnacort) and neomycin-hydrocortamate (neo-magnacort) ointment in dermatology.
1959-01
Patents

Patents

CA2550811A1
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Irrigation
In Vitro Use Guide
Unknown
Name Type Language
MAGNACORT
Preferred Name English
HYDROCORTAMATE HYDROCHLORIDE
MART.   MI   ORANGE BOOK  
Common Name English
HYDROCORTAMATE HCL
Common Name English
HYDROCORTAMATE HYDROCHLORIDE [MART.]
Common Name English
NSC-12884
Code English
Hydrocortamate hydrochloride [WHO-DD]
Common Name English
HYDROCORTAMATE HYDROCHLORIDE [MI]
Common Name English
HYDROCORTAMATE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
11.BETA.,17.ALPHA.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 21-DIETHYLAMINOACETATE HYDROCHLORIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C521
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
Code System Code Type Description
MERCK INDEX
m1187
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY Merck Index
NCI_THESAURUS
C65863
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
PUBCHEM
31312
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
WIKIPEDIA
Hydrocortamate hydrochloride
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
ChEMBL
CHEMBL1201263
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
EPA CompTox
DTXSID301027630
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
DRUG BANK
DBSALT000686
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
CAS
125-03-1
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
FDA UNII
9QM8U7R83W
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
NSC
12884
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
ECHA (EC/EINECS)
204-723-4
Created by admin on Mon Mar 31 17:34:24 GMT 2025 , Edited by admin on Mon Mar 31 17:34:24 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of HYDROCORTAMATE
NIH
NCATS
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