U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C27H41NO6.ClH
Molecular Weight 512.078
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCORTAMATE HYDROCHLORIDE

SMILES

Cl.[H][C@@]12CC[C@](O)(C(=O)COC(=O)CN(CC)CC)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=AKQNAIYKSALPKV-OYHXESGYSA-N
InChI=1S/C27H41NO6.ClH/c1-5-28(6-2)15-23(32)34-16-22(31)27(33)12-10-20-19-8-7-17-13-18(29)9-11-25(17,3)24(19)21(30)14-26(20,27)4;/h13,19-21,24,30,33H,5-12,14-16H2,1-4H3;1H/t19-,20-,21-,24+,25-,26-,27-;/m0./s1

HIDE SMILES / InChI
Hydrocortamate is a synthetic glucocorticoid possessing anti-inflammatory properties and acting as a glucocorticoid receptor agonist. Hydrocortamate was used under the brand name Magnacor to treat inflammation due to corticosteroid-responsive dermatoses btut that usage has been discontinued.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL2034
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
MAGNACORT

Approved Use

Unknown
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
PubMed

PubMed

TitleDatePubMed
Hydrocortamate (magnacort) and neomycin-hydrocortamate (neo-magnacort) ointment in dermatology.
1959 Jan
[On the topical use of a new pharmacological association of enzymes, neomycin and hydrocortamate. Clinical contribution].
1965 Nov
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Irrigation
In Vitro Use Guide
Unknown
Name Type Language
HYDROCORTAMATE HYDROCHLORIDE
MART.   MI   ORANGE BOOK  
Common Name English
HYDROCORTAMATE HCL
Common Name English
HYDROCORTAMATE HYDROCHLORIDE [MART.]
Common Name English
NSC-12884
Code English
Hydrocortamate hydrochloride [WHO-DD]
Common Name English
MAGNACORT
Brand Name English
HYDROCORTAMATE HYDROCHLORIDE [MI]
Common Name English
HYDROCORTAMATE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
11.BETA.,17.ALPHA.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 21-DIETHYLAMINOACETATE HYDROCHLORIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C521
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
Code System Code Type Description
MERCK INDEX
m1187
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C65863
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
PUBCHEM
31312
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
WIKIPEDIA
Hydrocortamate hydrochloride
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201263
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID301027630
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
DRUG BANK
DBSALT000686
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
CAS
125-03-1
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
FDA UNII
9QM8U7R83W
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
NSC
12884
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
204-723-4
Created by admin on Fri Dec 15 14:59:39 GMT 2023 , Edited by admin on Fri Dec 15 14:59:39 GMT 2023
PRIMARY