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Description
Curator's Comment:: Description was created based on several sources, including https://www.drugs.com/cdi/gonadorelin.html

Gonadorelin is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use. Gonadorelin is used for the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
10.0 nM [IC50]
Target ID: Q96P88
Gene ID: NA
Gene Symbol: GNRHR2
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
FACTREL

Approved Use

Hypogonadism (diagnosis)—Gonadorelin as a single dose (gonadorelin test) is indicated for evaluation of the functional capacity and response of gonadotropes in the anterior pituitary in postpubertal patients who are suspected of having gonadotropin deficiency, whether due to hypothalamic function impairment alone or in combination with anterior pituitary function failure.

Launch Date

4.02105598E11
Primary
FACTREL

Approved Use

Amenorrhea treatment

Launch Date

4.02105598E11
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: subcutaneous route is possible
Usual Adult Dose for Gonadotropin Deficiency 0.1 mg injected once subcutaneously or intravenously as a single dose. Usual Adult Dose for Amenorrhea 5 mcg every 90 minutes (range of 1 to 20 mcg) delivered intravenously by a pump over 1 minute, every ninety minutes for 21 days.
Route of Administration: Intravenous
In Vitro Use Guide
47 ng/ml Gonadorelin induced luteinizing hormone release in ovariectomized estrogen/progesterone-treated rat at 5 ng, sc measured at 30 mins post dose by RIA (Rvb = 5.3 +/- 1.5 ng/ml)
Name Type Language
GONADORELIN
INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
GONADORELIN [WHO-DD]
Common Name English
GONADOTROPIN-RELEASING HORMONE
Common Name English
GONADORELIN (GONADORELIN DECAPEPTIDE (GNRH))
Common Name English
GONADORELIN [MI]
Common Name English
GONADORELIN [VANDF]
Common Name English
5-OXOPRO-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2
Common Name English
LUTEINISING HORMONE-RELEASING FACTOR (LNRH) ANALOGUE
Common Name English
LUTEINIZING HORMONE-RELEASING FACTOR
Common Name English
GONADORELIN DECAPEPTIDE
Common Name English
LUTEINIZING HORMONE RELEASING FACTOR
Common Name English
GONADORELIN [INN]
Common Name English
GONADOTROPIN-RELEASING HORMONE (GNRH) ANALOGUE
Common Name English
GNRH
Common Name English
GONADORELIN [MART.]
Common Name English
PGLU-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2
Common Name English
LHRH
Common Name English
Classification Tree Code System Code
WHO-VATC QH01CA01
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
WHO-ATC H01CA01
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
WHO-VATC QV04CM01
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
EPA PESTICIDE CODE 116800
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
WHO-ATC V04CM01
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
Code System Code Type Description
EPA CompTox
9034-40-6
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
CAS
33515-09-2
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
DRUG CENTRAL
2958
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
PUBCHEM
638793
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
ECHA (EC/EINECS)
251-553-1
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
MERCK INDEX
M5831
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY Merck Index
CAS
9034-40-6
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
NO STRUCTURE GIVEN
MESH
D007987
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
FDA UNII
9O7312W37G
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
WIKIPEDIA
Gonadotropin-releasing hormone analogue
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
ChEMBL
CHEMBL1007
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
DRUG BANK
DB00644
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
INN
3627
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
NCI_THESAURUS
C613
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
EVMPD
SUB07960MIG
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY
RXCUI
6384
Created by admin on Sat Jun 26 00:06:14 UTC 2021 , Edited by admin on Sat Jun 26 00:06:14 UTC 2021
PRIMARY RxNorm