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Details

Stereochemistry ACHIRAL
Molecular Formula C14H16N2.ClH
Molecular Weight 248.751
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NAPACTADINE HYDROCHLORIDE

SMILES

Cl.CN\C(CC1=CC2=C(C=CC=C2)C=C1)=N/C

InChI

InChIKey=WEDBCIMSKMMRAG-UHFFFAOYSA-N
InChI=1S/C14H16N2.ClH/c1-15-14(16-2)10-11-7-8-12-5-3-4-6-13(12)9-11;/h3-9H,10H2,1-2H3,(H,15,16);1H

HIDE SMILES / InChI
Napactadine is a bicyclic antidepressant agent. It is a histamine-H1 receptor antagonist. Preliminary results indicated a marked improvement in depressive symptomalology within 7 days of treatment, as measured by the Hamilton depression scale. However, clinical studies were discontinued after chronic administration of napactadine because an elevation in liver enzyme levels was observed in some patients.

Approval Year

PubMed

PubMed

TitleDatePubMed
New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds.
1985 Nov
Name Type Language
NAPACTADINE HYDROCHLORIDE
MART.   USAN  
USAN  
Official Name English
2-NAPHTHALENEETHANIMIDAMIDE, N,N'-DIMETHYL-, MONOHYDROCHLORIDE
Common Name English
NAPACTADINE HYDROCHLORIDE [MART.]
Common Name English
NAPACTADINE HCL
Common Name English
NAPACTADINE HYDROCHLORIDE [USAN]
Common Name English
DL-588
Code English
N,N'-DIMETHYL-2-NAPHTHALENEACETAMIDINE MONOHYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C83984
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
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CAS
57166-13-9
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
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EPA CompTox
DTXSID80972630
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
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PUBCHEM
42152
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
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FDA UNII
9FB1F1BV0M
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
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ChEMBL
CHEMBL1192539
Created by admin on Fri Dec 15 16:30:38 GMT 2023 , Edited by admin on Fri Dec 15 16:30:38 GMT 2023
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