Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H8ClN5.ClH |
| Molecular Weight | 258.107 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC1=NC(NC2=CC=C(Cl)C=C2)=NC=N1
InChI
InChIKey=UYCMHUVQSSDLAM-UHFFFAOYSA-N
InChI=1S/C9H8ClN5.ClH/c10-6-1-3-7(4-2-6)14-9-13-5-12-8(11)15-9;/h1-5H,(H3,11,12,13,14,15);1H
Chlorazanil is a triazine derivative and diuretic agent. Chlorazanil appears to prevent the absorption of sodium and chloride in the distal convoluted tubule. As nonmercurial orally effective diuretic agent, Chlorazanil is prohibited in sport according to the regulations of the World Anti-Doping Agency (WADA).
Approval Year
Sample Use Guides
In conscious unloaded Sprague-Dawley female rats chlorazanil (10 mg/kg orally) markedly increased urinary prostaglandin E2-excretion from 51 +/- 9 to 813 +/- 112 ng/kg/6 hrs. Urinary flow rate increased from 12.8 +/- 0.6 to 42.0 +/- 1.4 ml/kg/6 hrs and urinary sodium excretion from 0.96 +/- 0.12 to 3.86 +/- 0.33 mmol/kg/6 hrs. Urinary potassium excretion was unchanged.
Route of Administration:
Oral
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NCI_THESAURUS |
C448
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ACTIVE MOIETY
SUBSTANCE RECORD
