CHLORAZANIL HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8ClN5.ClH
Molecular Weight	258.107
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC1=NC(NC2=CC=C(Cl)C=C2)=NC=N1

InChI

InChIKey=UYCMHUVQSSDLAM-UHFFFAOYSA-N

InChI=1S/C9H8ClN5.ClH/c10-6-1-3-7(4-2-6)14-9-13-5-12-8(11)15-9;/h1-5H,(H3,11,12,13,14,15);1H

HIDE SMILES / InChI

Molecular Formula	C9H8ClN5
Molecular Weight	221.646
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C79796 | https://www.ncbi.nlm.nih.gov/pubmed/26226108 | https://www.ncbi.nlm.nih.gov/pubmed/13626844

Chlorazanil is a triazine derivative and diuretic agent. Chlorazanil appears to prevent the absorption of sodium and chloride in the distal convoluted tubule. As nonmercurial orally effective diuretic agent, Chlorazanil is prohibited in sport according to the regulations of the World Anti-Doping Agency (WADA).

Originator

Approval Year

PubMed

Title	Date	PubMed
[Acute interstitial nephritis caused by drugs].	1983 May 20	6840011

Sample Use Guides

In Vivo Use Guide

In conscious unloaded Sprague-Dawley female rats chlorazanil (10 mg/kg orally) markedly increased urinary prostaglandin E2-excretion from 51 +/- 9 to 813 +/- 112 ng/kg/6 hrs. Urinary flow rate increased from 12.8 +/- 0.6 to 42.0 +/- 1.4 ml/kg/6 hrs and urinary sodium excretion from 0.96 +/- 0.12 to 3.86 +/- 0.33 mmol/kg/6 hrs. Urinary potassium excretion was unchanged.

Route of Administration: Oral

In Vitro Use Guide

In vitro chlorazanil (10(-4) M) exhibited a moderate inhibition of 15-OH-prostaglandin dehydrogenase.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:16 GMT 2023` Edited by `admin` on `Fri Dec 15 15:05:16 GMT 2023`
Record UNII	9961SL881J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORAZANIL HYDROCHLORIDE

Common Name

English

CHLORAZANIL HCL

Common Name

English

NSC-60256

Code

English

DOCLIZID-T

Brand Name

English

CHLORAZANIL HYDROCHLORIDE [MART.]

Common Name

English

Chlorazanil hydrochloride [WHO-DD]

Common Name

English

2-AMINO-4-P-CHLOROANILINO-S-TRIAZINE HYDROCHLORIDE

Common Name

English

CHLORAZANIL HYDROCHLORIDE [MI]

Common Name

English

ORPIDAN

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C448