U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
Studies on the calcemic effect of intravenous secretin in humans.
1975 Jun
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.
2000 Dec
Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
2001 Apr
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.
2001 Apr 27
Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.
2001 Apr 7
Complement activation in factor D-deficient mice.
2001 Dec 4
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.
2001 Jul
Analysis of the native quaternary structure of vanilloid receptor 1.
2001 Jul 27
Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B.
2001 Jun
Vasopressin-stimulated Ca2+ spiking in vascular smooth muscle cells involves phospholipase D.
2001 Jun
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Cloning and characterization of a novel human histamine receptor.
2001 Mar
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines.
2001 Mar
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.
2001 Mar 15
Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes.
2001 Mar 2
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
2001 Mar 27
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.
2001 Nov
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
2001 Nov 30
Familial intrahepatic cholestasis 1: studies of localization and function.
2001 Oct
Microarray analysis of differential gene expression in lead-exposed astrocytes.
2001 Oct 1
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.
2001 Oct 12
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.
2001 Sep
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism.
2001 Sep
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.
2001 Sep 1
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.
2001 Sep 15
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
2001 Sep 7
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
2002
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.
2002 Dec
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.
2002 Feb
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002 Feb
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.
2002 Jul
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
2002 Jul 5
Human kidney diamine oxidase: heterologous expression, purification, and characterization.
2002 Jun
Expression of functional CCR and CXCR chemokine receptors in podocytes.
2002 Jun 15
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
2002 Mar
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
2002 Mar
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.
2002 Mar 15
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.
2002 May 15
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.
2002 Nov 4
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.
2002 Sep
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
2002 Sep 15
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.
2002 Sep 6
A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.
2002 Sep 6
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
2003 Jan
Patents

Sample Use Guides

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
CALCIUM PHOSPHATE
EP   II   INCI   MART.   VANDF   WHO-DD  
INCI  
Preferred Name English
CALCIUM PHOSPHATE, UNSPECIFIED FORM
Common Name English
CALCIUM PHOSPHATE [VANDF]
Common Name English
CALCIUM PHOSPHATE [INCI]
Common Name English
CALCIUM PHOSPHATE [II]
Common Name English
CALCIUM PHOSPHATE [EP IMPURITY]
Common Name English
CALCIUM PHOSPHATE [MART.]
Common Name English
PHOSPHORIC ACID, CALCIUM SALT
Common Name English
TRICALCII PHOSPHAS
Common Name English
CALCIUM PHOSPHATE [EP MONOGRAPH]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 331.15
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
WHO-VATC QA12AA01
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
CFR 21 CFR 331.11
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EPA PESTICIDE CODE 76401
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
WHO-ATC A12AA01
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LOINC 32137-2
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Code System Code Type Description
EVMPD
SUB127040
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ALTERNATIVE
NCI_THESAURUS
C45678
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CONCEPT Industrial Aid
RXCUI
1919
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY RxNorm
FDA UNII
97Z1WI3NDX
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
CHEBI
9679
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
CAS
10103-46-5
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NON-SPECIFIC STOICHIOMETRY
DAILYMED
97Z1WI3NDX
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
EVMPD
SUB127041
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
ALTERNATIVE
NCI_THESAURUS
C120560
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PRIMARY
SMS_ID
100000088337
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PRIMARY
MESH
C020243
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
EVMPD
SUB20364
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
ECHA (EC/EINECS)
233-283-6
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
DRUG CENTRAL
4441
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
EVMPD
SUB127042
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
ALTERNATIVE
DRUG BANK
DB11348
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
EPA CompTox
DTXSID40893099
Created by admin on Fri Dec 15 16:04:19 GMT 2023 , Edited by admin on Fri Dec 15 16:04:19 GMT 2023
PRIMARY
Definition References