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Details

Stereochemistry ACHIRAL
Molecular Formula Ca.HO4P
Molecular Weight 136.057
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANHYDROUS DIBASIC CALCIUM PHOSPHATE

SMILES

[Ca++].OP([O-])([O-])=O

InChI

InChIKey=FUFJGUQYACFECW-UHFFFAOYSA-L
InChI=1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO4P
Molecular Weight 95.9793
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
Studies on the calcemic effect of intravenous secretin in humans.
1975 Jun
Effects of terbutaline on force and intracellular calcium in slow-twitch skeletal muscle fibres of the rat.
1999 Apr
Transient kinetic analysis of the 130-kDa myosin I (MYR-1 gene product) from rat liver. A myosin I designed for maintenance of tension?
1999 Jul 30
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
1999 Sep
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.
2000 Dec
Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.
2000 Dec
D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade.
2000 Dec 15
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
2000 Jan 7
Polyoxygenated dysidea sterols that inhibit the binding of [I125] IL-8 to the human recombinant IL-8 receptor type A.
2000 May
Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway.
2000 May
Inhibition of proteolysis by a cyclooxygenase inhibitor, indomethacin.
2000 Nov
Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells.
2000 Nov
High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension.
2000 Sep
ATP induces dephosphorylation of myosin light chain in endothelial cells.
2000 Sep
Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.
2001 Apr 7
Complement activation in factor D-deficient mice.
2001 Dec 4
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.
2001 Jul
Analysis of the native quaternary structure of vanilloid receptor 1.
2001 Jul 27
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Cloning and characterization of a novel human histamine receptor.
2001 Mar
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines.
2001 Mar
Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes.
2001 Mar 2
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.
2001 Nov
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
2001 Oct 26
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.
2001 Sep 15
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
2001 Sep 7
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.
2002 Dec
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002 Feb
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Human kidney diamine oxidase: heterologous expression, purification, and characterization.
2002 Jun
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.
2002 Mar 15
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.
2002 May 15
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.
2002 Nov 4
Effects of ultrasound treatment on physico-chemical, functional properties and antioxidant activity of whey protein isolate in the presence of calcium lactate.
2018 Mar
Patents

Sample Use Guides

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:30:58 UTC 2023
Edited
by admin
on Fri Dec 15 15:30:58 UTC 2023
Record UNII
L11K75P92J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM PHOSPHATE, DIBASIC, ANHYDROUS
II  
Preferred Name English
ANHYDROUS DIBASIC CALCIUM PHOSPHATE
USP  
Common Name English
CALCIUM PHOSPHATE DIBASIC
WHO-DD  
Common Name English
CALCIUM PHOSPHATE (DIBASIC)
Common Name English
CALCIUM HYDROGEN PHOSPHATE ANHYDROUS
Common Name English
CALCIUM HYDROGEN ORTHOPHOSPHATE
Systematic Name English
DICALCIUM PHOSPHATE
INCI  
INCI  
Official Name English
INS-341(II)
Code English
CALCII HYDROGENOPHOSPHAS [WHO-IP LATIN]
Common Name English
CALCIUM PHOSPHATE, DIBASIC, ANHYDROUS [II]
Common Name English
CALCIUM PHOSPHATE, DIBASIC
HSDB   MI  
Common Name English
CALCIUM PHOSPHATE,DIBASIC [VANDF]
Common Name English
CALCIUM PHOSPHATE, DIBASIC ANHYDROUS
Common Name English
PHOSPHORUS (AS DICALCIUM PHOSPHATE) [VANDF]
Common Name English
CALCIUM MONOHYDROGEN PHOSPHATE
Systematic Name English
PHOSPHORUS (AS CALCIUM PHOSPHATE,DIBASIC) [VANDF]
Common Name English
CALCIUM PHOSPHATE, DIBASIC [HSDB]
Common Name English
DICALCIUM ORTHOPHOSPHATE
Systematic Name English
PHOSPHORUS (AS DICALCIUM PHOSPHATE)
VANDF  
Common Name English
DIBASIC CALCIUM PHOSPHATE ANHYDROUS
Common Name English
Calcium phosphate dibasic [WHO-DD]
Common Name English
CALCIUM PHOSPHATE, DIBASIC [MI]
Common Name English
CALCIUM HYDROGEN MONOPHOSPHATE
Systematic Name English
ANHYDROUS DIBASIC CALCIUM PHOSPHATE [USP MONOGRAPH]
Common Name English
DIBASIC CALCIUM PHOSPHATE
Common Name English
CALCIUM (CALCIUM PHOSPHATE (DIBASIC))
Common Name English
CALCIUM HYDROGEN PHOSPHATE [EP MONOGRAPH]
Common Name English
CALCIUM (AS PHOSPHATE,DIBASIC) [VANDF]
Common Name English
DICALCIUM PHOSPHATE [INCI]
Common Name English
INS NO.341(II)
Code English
CALCIUM HYDROGEN PHOSPHATE, ANHYDROUS [WHO-IP]
Common Name English
CALCIUM PHOSPHATE (1:1) [WHO-IP]
Common Name English
E-341(II)
Code English
ANHYDROUS DIBASIC CALCIUM PHOSPHATE [JAN]
Common Name English
CALCIUM HYDROGEN PHOSPHATE (ANHYDROUS)
Common Name English
PHOSPHORIC ACID, CALCIUM SALT (1:1)
Common Name English
CALCIUM HYDROGEN PHOSPHATE
Systematic Name English
SECONDARY CALCIUM PHOSPHATE
Common Name English
CALCIUM PHOSPHATE (1:1)
WHO-IP  
Systematic Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-341(II)
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
JECFA EVALUATION INS-341(II)
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
Code System Code Type Description
PUBCHEM
24441
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
RXCUI
47627
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
SMS_ID
100000087353
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
DAILYMED
L11K75P92J
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
WIKIPEDIA
DICALCIUM PHOSPHATE
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ANHYDROUS DIBASIC CALCIUM PHOSPHATE
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY Description: A white or almost white powder; odourless. Solubility: Practically insoluble in cold water and ethanol (~750 g/l) TS; soluble in dilute acids. Category: Tablet and capsule diluent. Storage: Calcium hydrogen phosphate should be kept in a well-closed container. Labelling: The designation on the container of Calcium hydrogen phosphate should state whether it is the dihydrate or the anhydrous form. Requirement: Calcium hydrogen phosphate contains not less than 30.9% and not more than the equivalent of 31.7% of calcium, Ca, calculated with reference to the ignited substance.
FDA UNII
L11K75P92J
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
DRUG BANK
DBSALT002430
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
CHEBI
32596
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PRIMARY
CHEBI
4496
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PRIMARY
NCI_THESAURUS
C77523
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
MERCK INDEX
m2964
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PRIMARY Merck Index
ChEMBL
CHEMBL2107567
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PRIMARY
ECHA (EC/EINECS)
231-826-1
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
HSDB
992
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
EPA CompTox
DTXSID20872529
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
CONCEPT Dietary Supplement
EVMPD
SUB16368MIG
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PRIMARY
RXCUI
253163
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
ALTERNATIVE
EVMPD
SUB11772MIG
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
CAS
7757-93-9
Created by admin on Fri Dec 15 15:30:58 UTC 2023 , Edited by admin on Fri Dec 15 15:30:58 UTC 2023
PRIMARY
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